The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27876467 |
9 |
A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease. |
Tehran University of Medical Sciences |
| 24731278 |
22 |
Synthesis and in vitro evaluation of anti-inflammatory activity of ester and amine derivatives of indoline in RAW 264.7 and peritoneal macrophages. |
Bar-Ilan University |
| 24148993 |
4 |
Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. |
Punjabi University |
| 23199476 |
36 |
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase. |
Universit£ |
| 15317459 |
46 |
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis. |
Universitat De Barcelona |
| 23151013 |
56 |
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease. |
Bar-Ilan University |
| 22243648 |
112 |
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, andß-amyloid-reducing properties. |
Instituto De Qu£Mica M£Dica |
| 22185619 |
50 |
Huprine-tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer's and prion diseases. |
Universitat De Barcelona |
| 20575555 |
45 |
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives. |
Universidad Autonoma De Madrid |
| 20176490 |
8 |
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. |
Institute of Plant Biochemistry |
| 18517184 |
47 |
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation. |
Laboratori De Qu�Mica Farmac�Utica (Unitat Associada Al Csic) |
| 18479118 |
114 |
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors. |
Universit£ |
| 17854153 |
2 |
Brunneins A-C, beta-carboline alkaloids from Cortinarius brunneus. |
Institute of Plant Biochemistry |
| 17904850 |
3 |
Cryptadines A and B, novel C27N3-type pentacyclic alkaloids from Lycopodium cryptomerinum. |
Hoshi University |
| 17154513 |
56 |
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole. |
Universitat De Barcelona |
| 15139762 |
133 |
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship. |
University of Hamburg |
| 12502352 |
28 |
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors. |
Universit£ |
| 11831902 |
12 |
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors. |
Institute of Research |
| 11741490 |
18 |
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors. |
Universitat De Barcelona |
| 11101357 |
84 |
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease. |
Universitat De Barcelona |
| 10464010 |
40 |
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease. |
Universitat De Barcelona |
| 2033583 |
10 |
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity. |
University of Iowa |
| 2913310 |
68 |
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases. |
Sri International |
| 12031333 |
5 |
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B. |
Georgetown University Medical Center |
| 11078202 |
4 |
Synthesis, chiral chromatographic separation, and biological activities of the enantiomers of 10,10-dimethylhuperzine A. |
Georgetown University Medical Center |
| | 9 |
Synthesis of ()-10,10-dimethylhuperzine A a huperzine analogue possessing a slower enzyme off-rate |
TBA |
| 21420206 |
38 |
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease. |
Instituto De Qu£Mica M£Dica |
| 21459491 |
96 |
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease. |
Universit£ |
| 21417225 |
116 |
Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity. |
Universidad De Granada |
| 21163662 |
39 |
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles. |
Laboratorio De Radicales Libres Y Qu�Mica Computacional (Iqog, Csic) |
| 20926162 |
14 |
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases. |
Instituto De Qu£Mica M£Dica |
| 20545360 |
38 |
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties. |
Instituto De Quimica Medica |
| 19856923 |
40 |
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease. |
Instituto De Quimica Medica (Csic) |
| | 22 |
Synthesis, insecticidal and anti-acetylcholinesterase activity of a new class of heterocyclic methanesulfonates |
TBA |
| 18585045 |
22 |
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors. |
Università |
| 18485717 |
3 |
Lycoparins A-C, new alkaloids from Lycopodium casuarinoides inhibiting acetylcholinesterase. |
Hoshi University |
| 17188496 |
3 |
Carinatumins A-C, new alkaloids from Lycopodium carinatum inhibiting acetylcholinesterase. |
Hoshi University |
| 30739821 |
57 |
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines. |
Hospital Universitario De La Princesa |
| 9871563 |
31 |
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase. |
Istituto Di Strutturistica Chimica G. Giacomello |
| 30744931 |
170 |
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018). |
Csir-Central Drug Research Institute |
| 9301662 |
50 |
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase. |
University of North Texas |
| 29609119 |
9 |
Benzopyrroloxazines containing a bridgehead nitrogen atom as promising scaffolds for the achievement of biologically active agents. |
University of Calabria |
| 29605809 |
19 |
Success stories of natural product-based hybrid molecules for multi-factorial diseases. |
Punjabi University |
| 29886321 |
20 |
Rational design of carbamate-based dual binding site and central AChE inhibitors by a "biooxidisable" prodrug approach: Synthesis, in vitro evaluation and docking studies. |
Cnrs |
| 28371641 |
32 |
Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease. |
China Pharmaceutical University |
| 10411562 |
36 |
Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles. |
Merck Frosst Centre For Therapeutic Research |
| 15239652 |
22 |
Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors. |
Fujisawa Pharmaceutical |
| 17941623 |
72 |
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1. |
St. Jude Research Hospital |
| 17154493 |
13 |
4,5-dihydroxypyrimidine carboxamides and N-alkyl-5-hydroxypyrimidinone carboxamides are potent, selective HIV integrase inhibitors with good pharmacokinetic profiles in preclinical species. |
Irbm-Mrl |
Search and Browse
