85 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27216999	30	Protective effect of novel substituted nicotine hydrazide analogues against hypoxic brain injury in neonatal rats via inhibition of caspase.	The Fifth Affiliated Hospital of Guangzhou Medical University
25171780	7	Design, synthesis, and structure-activity relationships of novel benzothiazole derivatives bearing the ortho-hydroxy N-carbamoylhydrazone moiety as potent antitumor agents.	Key Laboratory of Structure-Based Drug Design and Discovery (Shenyang Pharmaceutical University) Ministry of Education
25011914	2	In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus.	Pukyong National University
25468037	76	Synthesis and evaluation of N-acyl-substituted 1,2-benzisothiazol-3-one derivatives as caspase-3 inhibitors.	TBA
25358116	84	Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.	Westf£Lische Wilhelms-Universit£T M£Nster
24656804	44	1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors.	Tianjin University of Science and Technology
23685941	53	Influence of 4- or 5-substituents on the pyrrolidine ring of 5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin derivatives on their inhibitory activities towards caspases-3 and -7.	Westf£Lische Wilhelms-Universit£T M£Nster
23632366	33	Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors.	Nankai University
23656488	18	Synthesis, 18F-radiolabeling, and in vivo biodistribution studies of N-fluorohydroxybutyl isatin sulfonamides using positron emission tomography.	Westf£Lische Wilhelms-Universit£T M£Nster
23411396	60	Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.	Westf£Lische Wilhelms-Universit£T M£Nster
24900651	50	Irreversible inhibitors of cysteine proteases.	Dart Neuroscience
22503362	35	New description of protein-ligand interactions using a spherical self-organizing map.	Chugai Pharmaceutical
22224594	346	Discovery and structure-activity relationship of potent and selective covalent inhibitors of transglutaminase 2 for Huntington's disease.	Evotec (Uk)
22652225	27	A novel class of small-molecule caspase-3 inhibitors prepared by multicomponent reactions.	Southern Medical University
22276851	4	Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.	University of Montana
21324681	23	Isatin 1,2,3-triazoles as potent inhibitors against caspase-3.	University of Oslo
19715320	87	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.	University of Florida
16870441	30	Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter and Gamble Pharmaceuticals
16046125	18	Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.	Procter & Gamble Pharmaceuticals
15214773	76	Fragment-based drug discovery.	Sunesis Pharmaceuticals
10669559	180	Protease inhibitors: current status and future prospects.	University of Queensland
14980679	30	Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.	Maxim Pharmaceuticals
9873373	20	Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases).	Institute For Drug Research
21903398	88	Exploiting differences in caspase-2 and -3 S2 subsites for selectivity: structure-based design, solid-phase synthesis and in vitro activity of novel substrate-based caspase-2 inhibitors.	Chdi Management
21439692	8	Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway.	University of Lisbon
21441025	147	Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.	Washington University
20541849	21	Synthesis and evaluation of vinyl sulfones as caspase-3 inhibitors. A structure-activity study.	University of Lisbon
20154666	1	Turning enzymes ON with small molecules.	University of California
17948018	17	Mechanisms, biology and inhibitors of deubiquitinating enzymes.	Institute For Bio-Medical Research
19631549	18	Design, synthesis, and discovery of novel non-peptide inhibitor of Caspase-3 using ligand based and structure based virtual screening approach.	Osmania University College For Women
19445513	82	Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.	Westfalische Wilhelms-Universitat
19299147	60	Fluorinated isatin derivatives. Part 1: synthesis of new N-substituted (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatins as potent caspase-3 and -7 inhibitors.	WestfäLische Wilhelms-UniversitäT
19049429	70	Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.	Imperial College
18387304	4	Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3.	Tokyo University of Science
17889532	23	Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.	Epicept
17585855	65	Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.	Washington University
17251019	30	Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.	Merck Frosst Centre For Therapeutic Research
17181147	10	Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.	University of Edinburgh
17154501	121	5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.	University Hospital of The WestfäLische Wilhelms-UniversitäT
17127070	61	Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter & Gamble Pharmaceuticals
16891117	5	Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.	Washington University
16782334	61	Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter & Gamble Pharmaceuticals
16216507	87	Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.	Procter & Gamble Pharmaceuticals
16078840	94	Discovery and structure-activity relationship of 3-aryl-5-aryl-1,2,4-oxadiazoles as a new series of apoptosis inducers and potential anticancer agents.	Maxim Pharmaceuticals
16046129	18	Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.	Procter & Gamble Pharmaceuticals
15808464	32	Kinesin spindle protein (KSP) inhibitors. Part 1: The discovery of 3,5-diaryl-4,5-dihydropyrazoles as potent and selective inhibitors of the mitotic kinesin KSP.	Merck Research Laboratories
15713391	19	Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P2 alpha-amino acid by a alpha-hydroxy acid.	Maxim Pharmaceuticals
15686936	210	Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.	Merck Frosst Centre For Therapeutic Research
15588079	1	Design and synthesis of a potent and selective peptidomimetic inhibitor of caspase-3.	University of Illinois At Chicago
15454214	26	Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group.	Maxim Pharmaceuticals
15109679	15	Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.	Idun Pharmaceuticals
14505683	6	Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.	Idun Pharmaceuticals
12270186	99	Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.	Idun Pharmaceuticals
12270185	257	Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.	Idun Pharmaceuticals
12127536	22	Discovery of potent, selective human granzyme B inhibitors that inhibit CTL mediated apoptosis.	Merck Research Laboratories
10978183	40	Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.	Basf Bioresearch
9873617	30	Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain).	Idun Pharmaceuticals
28820254	17	Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis.	Emory Chemical Biology Discovery Center Emory University School of Medicine Atlanta
12757844	9	In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand.	Merck Research Laboratories
11512051	80	The in vitro pharmacology of the beta-adrenergic receptor pet ligand (s)-fluorocarazolol reveals high affinity for cloned beta-adrenergic receptors and moderate affinity for the human 5-HT1A receptor.	Case Western Reserve University
9108306	17	Molecular cloning and characterization of a new receptor for galanin.	Merck Research Laboratories
18844338	4	Virtual screening to successfully identify novel janus kinase 3 inhibitors: a sequential focused screening approach.	Johnson & Johnson Pharmaceutical
18006306	12	Biphenyl amide p38 kinase inhibitors 1: Discovery and binding mode.	Gsk
18812261	8	The molecular interactions of buspirone analogues with the serotonin transporter.	National Medicines Institute
18307303	75	Discovery of selective aminothiazole aurora kinase inhibitors.	Novartis
18834107	22	Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors.	The Scripps Research Institute
18855373	10	Structure-based virtual screening and biological evaluation of Mycobacterium tuberculosis adenosine 5'-phosphosulfate reductase inhibitors.	The Scripps Research Institute
18800762	61	Inhibition of geranylgeranyl diphosphate synthase by bisphosphonates: a crystallographic and computational investigation.	National Taiwan University
18308563	39	Probing the elusive catalytic activity of vertebrate class IIa histone deacetylases.	Irbm/Merck Research Laboratories
17685602	33	Discovery of 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol as an isozyme-selective inhibitor of PI3K for the treatment of ischemia reperfusion injury associated with myocardial infarction.	Targegen
18754654	19	The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer .	Piramed Pharma
18800763	93	Identification of 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-{[(3S)-3-piperidinylmethyl]oxy}-1H-imidazo[4,5-c]pyridin-4-yl)-2-methyl-3-butyn-2-ol (GSK690693), a novel inhibitor of AKT kinase.	Glaxosmithkline
17766111	17	Kinesin spindle protein (KSP) inhibitors. Part 8: Design and synthesis of 1,4-diaryl-4,5-dihydropyrazoles as potent inhibitors of the mitotic kinesin KSP.	Merck Research Laboratories
32272481	9	Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors	Shanghaitech University
14698155	68	Synthesis and evaluation of indenopyrazoles as cyclin-dependent kinase inhibitors. Part 4: Heterocycles at C3.	Bristol-Myers Squibb