47 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27939174	84	Challenges in the development of an M	Vanderbilt University Medical Center
27185330	60	Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core.	Vanderbilt University Medical Center
25147929	105	Development of a highly potent, novel M5 positive allosteric modulator (PAM) demonstrating CNS exposure: 1-((1H-indazol-5-yl)sulfoneyl)-N-ethyl-N-(2-(trifluoromethyl)benzyl)piperidine-4-carboxamide (ML380).	Vanderbilt University Medical Center
24164599	9	Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1H-imidazo[2,1-a]isoindol-5(9bH)-one (ML375).	Vanderbilt University
23562060	9	Discovery of ML326: The first sub-micromolar, selective M5 PAM.	Vanderbilt University Medical Center
23200253	67	Further exploration of M1 allosteric agonists: subtle structural changes abolish M1 allosteric agonism and result in pan-mAChR orthosteric antagonism.	Vanderbilt University Medical Center
23177787	59	Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia.	Vanderbilt University Medical Center
9767650	48	Universal template approach to drug design: polyamines as selective muscarinic receptor antagonists.	University of Bologna
18178088	64	Synthesis and SAR of selective muscarinic acetylcholine receptor subtype 1 (M1 mAChR) antagonists.	Vanderbilt Institute of Chemical Biology
16250647	71	2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.	Universit£
9622546	109	6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.	National Institute of Diabetes and Digestive and Kidney Diseases
7562924	10	Resolution and in vitro and initial in vivo evaluation of isomers of iodine-125-labeled 1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo-1-propen-3-yl)-alpha-phenylacetate: a high-affinity ligand for the muscarinic receptor.	Oak Ridge National Laboratory (Ornl)
21930376	92	Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071.	Vanderbilt University Medical Center
18059262	9	An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission.	Dvanderbilt Program In Drug Discovery
20004578	28	Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM.	Vanderbilt University Medical Center
	8	Alzheimer's therapy: an approach to novel muscarinic ligands based upon the naturally occurring alkaloid himbacine.	TBA
19438238	45	Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins.	Vanderbilt University Medical Center
31787491	54	Discovery of structurally distinct tricyclic M	Vanderbilt University
31784320	31	Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M	Vanderbilt University
27476142	104	Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition.	Vanderbilt University School of Medicine
31248774	45	SAR inspired by aldehyde oxidase (AO) metabolism: Discovery of novel, CNS penetrant tricyclic M	Vanderbilt University
30106578	10	Allosteric Modulation of Class A GPCRs: Targets, Agents, and Emerging Concepts.	TBA
29652494	18	Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand.	University of Shizuoka
29037946	50	Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M	Vanderbilt University
2066986	137	Functionalized congener approach to muscarinic antagonists: analogues of pirenzepine.	Niddk
28633897	73	Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists.	Vanderbilt University School of Medicine
28866269	61	Discovery of a novel, CNS penetrant M	Vanderbilt University
28442253	68	Optimization of M	Vanderbilt University Medical Center
28427812	74	Synthesis and evaluation of 4,6-disubstituted pyrimidines as CNS penetrant pan-muscarinic antagonists with a novel chemotype.	Vanderbilt University School of Medicine
23548908	1	Inhibition of isoleucyl-tRNA synthetase as a potential treatment for human African Trypanosomiasis.	University of Washington
26051755	2	New monomeric and dimeric uridinyl derivatives as inhibitors of chitin synthase.	Silesian University of Technology