The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28230981 |
37 |
High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. |
University of California |
28099811 |
23 |
Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. |
University of California |
26041577 |
13 |
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis. |
Istituto Giannina Gaslini |
25019478 |
13 |
Flavones: an important scaffold for medicinal chemistry. |
Punjabi University |
25452003 |
4 |
¿F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. |
Wuhan University of Science and Technology |
25441013 |
49 |
Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. |
Vertex Pharmaceuticals |
25384240 |
4 |
Discovery heralds new approach to the treatment of cystic fibrosis. |
Jl3Pharma |
24992073 |
2 |
A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo. |
Universit£ |
23814642 |
1 |
ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. |
University of California |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University of Oxford |
21707078 |
31 |
Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. |
University of California |
21397997 |
5 |
An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors. |
University Joseph Fourier-Grenoble 1/Cnrs |
19785436 |
29 |
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. |
University of California |
18691893 |
43 |
Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. |
University of California |
18180157 |
10 |
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains. |
St. Jude Children'S Research Hospital |
15808474 |
43 |
Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport. |
Genzyme |
14761197 |
16 |
Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels. |
Université |
27563392 |
9 |
Targeting the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein for the Treatment of Cystic Fibrosis. |
Therachem Research Medilab (India) |
31326599 |
21 |
An overview on chemical structures as ?F508-CFTR correctors. |
University of Palermo |
31401008 |
34 |
Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. |
Y. B. Chavan College of Pharmacy |
31749908 |
25 |
Discovery of ABBV/GLPG-3221, a Potent Corrector of CFTR for the Treatment of Cystic Fibrosis. |
Abbvie |
26561003 |
25 |
Novel Hits in the Correction of ?F508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Protein: Synthesis, Pharmacological, and ADME Evaluation of Tetrahydropyrido[4,3-d]pyrimidines for the Potential Treatment of Cystic Fibrosis. |
Siena Biotech |
25061695 |
23 |
Constrained bithiazoles: small molecule correctors of defective ?F508-CFTR protein trafficking. |
University of California |
22841006 |
5 |
Click-based synthesis of triazolobithiazole ?F508-CFTR correctors for cystic fibrosis. |
University of California Davis |
22214395 |
14 |
Structure-activity relationships of cyanoquinolines with corrector-potentiator activity in ?F508 cystic fibrosis transmembrane conductance regulator protein. |
University of California Davis |
22281185 |
3 |
Fluorinated ?F508-CFTR correctors and potentiators for PET imaging. |
University of California Davis |
20373765 |
10 |
Pyrazolylthiazole as DeltaF508-cystic fibrosis transmembrane conductance regulator correctors with improved hydrophilicity compared to bithiazoles. |
University of California Davis |
18394886 |
9 |
4'-Methyl-4,5'-bithiazole-based correctors of defective delta F508-CFTR cellular processing. |
University of California |
30078607 |
1 |
Asperidines A-C, pyrrolidine and piperidine derivatives from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. |
Prince of Songkla University |
30034584 |
18 |
Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Protein. |
Usona Institute |
29272749 |
126 |
Synthesis and biological evaluation of novel thiazole- VX-809 hybrid derivatives as F508del correctors by QSAR-based filtering tools. |
University of Genoa |
2005579 |
23 |
N-[3H]methylscopolamine labeling of non-M1, non-M2 muscarinic receptor binding sites in rat brain. |
University of California |
17157021 |
47 |
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors. |
Gsk |
17941625 |
50 |
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
Methylgene |
17552508 |
128 |
Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates. |
Duquesne University |
16963264 |
22 |
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. |
Bristol-Myers Squibb Pharmaceutical Research Institute |