The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27994752 |
28 |
Identification of an Orally Efficacious GPR40/FFAR1 Receptor Agonist. |
Cadila Healthcare |
| 26620255 |
42 |
Discovery of the imidazole-derived GPR40 agonist AM-3189. |
Amgen |
| 18479920 |
68 |
Synthesis and SAR of potent and orally bioavailable tert-butylpyrrolidine archetype derived melanocortin subtype-4 receptor modulators. |
Merck Research Laboratories |
| 20621473 |
56 |
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists. |
Merck Research Laboratories |
| 20207541 |
18 |
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist. |
Merck Research Laboratories |
| 18417348 |
82 |
Pharmacological and pharmacokinetic characterization of 2-piperazine-alpha-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists. |
Neurocrine Biosciences |
| 17822895 |
110 |
Pyrrolidinones as potent functional antagonists of the human melanocortin-4 receptor. |
Neurocrine Biosciences |
| 17544282 |
39 |
Pyrrolidinones as orally bioavailable antagonists of the human melanocortin-4 receptor with anti-cachectic activity. |
Neurocrine Biosciences |
| 15982875 |
46 |
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist. |
Merck Research Laboratories |
| 15857110 |
96 |
Discovery of a beta-MSH-derived MC-4R selective agonist. |
Eli Lilly |
| 12361385 |
34 |
Design and pharmacology of N-[(3R)-1,2,3,4-tetrahydroisoquinolinium- 3-ylcarbonyl]-(1R)-1-(4-chlorobenzyl)- 2-[4-cyclohexyl-4-(1H-1,2,4-triazol- 1-ylmethyl)piperidin-1-yl]-2-oxoethylamine (1), a potent, selective, melanocortin subtype-4 receptor agonist. |
Merck |
| 30655940 |
29 |
Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid ?-Fluorination. |
Janssen Research & Development |
| 29705709 |
45 |
Design, synthesis and structure-activity relationship studies of GPR40 agonists containing amide linker. |
Chinese Academy of Sciences |
| 30034601 |
70 |
Structure-Activity Relationship of Novel and Selective Biaryl-Chroman GPR40 AgoPAMs. |
Merck |
| 29236497 |
37 |
Discovery of LY3104607: A Potent and Selective G Protein-Coupled Receptor 40 (GPR40) Agonist with Optimized Pharmacokinetic Properties to Support Once Daily Oral Treatment in Patients with Type 2 Diabetes Mellitus. |
Eli Lilly |
| 19226504 |
5 |
On-chip fragment-based approach for discovery of high-affinity bivalent inhibitors. |
Antibiotics Laboratory |
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