The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 10633039 |
718 |
Pharmacophore/receptor models for GABA(A)/BzR subtypes (alpha1beta3gamma2, alpha5beta3gamma2, and alpha6beta3gamma2) via a comprehensive ligand-mapping approach. |
University of Wisconsin-Milwaukee |
| 20888240 |
254 |
Design, synthesis, and subtype selectivity of 3,6-disubstitutedß-carbolines at Bz/GABA(A)ergic receptors. SAR and studies directed toward agents for treatment of alcohol abuse. |
University of Wisconsin-Milwaukee |
| 15537339 |
18 |
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA alpha5 receptors with cognition enhancing properties. |
Merck Sharp & Dohme Research Laboratories |
| 15214791 |
147 |
Synthesis and biological evaluation of 3-heterocyclyl-7,8,9,10-tetrahydro-(7,10-ethano)-1,2,4-triazolo[3,4-a]phthalazines and analogues as subtype-selective inverse agonists for the GABA(A)alpha5 benzodiazepine binding site. |
Merck Sharp and Dohme Research Laboratories |
| 15006383 |
12 |
Determination of the stable conformation of GABA(A)-benzodiazepine receptor bivalent ligands by low temperature NMR and X-ray analysis. |
University of Wisconsin-Milwaukee |
| 14667209 |
32 |
Synthesis, in vitro affinity, and efficacy of a bis 8-ethynyl-4H-imidazo[1,5a]- [1,4]benzodiazepine analogue, the first bivalent alpha5 subtype selective BzR/GABA(A) antagonist. |
University of Wisconsin-Milwaukee |
| 11412984 |
66 |
Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors. |
The Royal Danish School of Pharmacy |
| 9767648 |
275 |
Predictive models for GABAA/benzodiazepine receptor subtypes: studies of quantitative structure-activity relationships for imidazobenzodiazepines at five recombinant GABAA/benzodiazepine receptor subtypes [alphaxbeta3gamma2 (x = 1-3, 5, and 6)] via comparative molecular field analysis. |
University of Wisconsin-Milwaukee |
| 9651158 |
158 |
Synthesis and evaluation of analogues of the partial agonist 6-(propyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (6-PBC) and the full agonist 6-(benzyloxy)-4-(methoxymethyl)-beta-carboline-3-carboxylic acid ethyl ester (Zk 93423) at wild type and recombinant GABAA receptors |
University of Wisconsin-Milwaukee |
| 28606760 |
57 |
Progress in the discovery of small molecule modulators of the Cys-loop superfamily receptors. |
Amgen |
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