The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
8691426 |
114 |
Synthesis and structure-activity relationships of 2-substituted D-tryptophan-containing peptidic endothelin receptor antagonists: importance of the C-2 substituent of the D-tryptophan residue for endothelin A and B receptor subtype selectivity. |
Tsukuba Research Institute |
1315867 |
31 |
Endothelin: a new challenge. |
Warner-Lambert |
9873432 |
52 |
Endothelin antagonists: discovery of EMD 122946, a highly potent and orally active ETA selective antagonist. |
Merck |
| 30 |
IRL 2500: A potent ETB selective endothelin antagonist |
TBA |
| 20 |
Synthesis of 2-substituted d-tryptophan-containing peptide derivatives with endothelin receptor antagonist activity |
TBA |
| 56 |
Pyridazinones with a pendant acylsulfonamide moiety as endothelin receptor antagonists |
TBA |
11985472 |
185 |
Structure-activity relationships of a novel class of endothelin-A receptor antagonists and discovery of potent and selective receptor antagonist, 2-(benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3-carboxylic acid (S-1255). 1. Study on structure-activity relationships and bas |
Shionogi |
11229770 |
28 |
Peptoids as endothelin receptor antagonists. |
Ranbaxy Laboratories |
10969989 |
45 |
Discovery and synthesis of a potent sulfonamide ET(B) selective antagonist. |
Shionogi |
27321813 |
286 |
From bosentan (TracleerŪ) to macitentan (OpsumitŪ): The medicinal chemistry perspective. |
Actelion Pharmaceuticals |
9379441 |
100 |
Pyrrolidine-3-carboxylic acids as endothelin antagonists. 2. Sulfonamide-based ETA/ETB mixed antagonists. |
Abbott Laboratories |
9022798 |
58 |
Potent and selective non-benzodioxole-containing endothelin-A receptor antagonists. |
Abbott Laboratories |
8676339 |
143 |
2,4-Diarylpyrrolidine-3-carboxylic acids--potent ETA selective endothelin receptor antagonists. 1. Discovery of A-127722. |
Abbott Laboratories |
8632420 |
112 |
Azole endothelin antagonists. 2. Structure-activity studies. |
Abbott Laboratories |
8632419 |
50 |
Azole endothelin antagonists. 1. A receptor model explains an unusual structure-activity profile. |
Abbott Laboratories |
7473559 |
85 |
Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists. |
Tsukuba Research Institute |