The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
1433224 |
1 |
Structure-activity studies on benzhydrol-containing nipecotic acid and guvacine derivatives as potent, orally-active inhibitors of GABA uptake. |
Warner-Lambert |
2544727 |
1 |
Sodium channel binding and anticonvulsant activities for the enantiomers of a bicyclic 2,4-oxazolidinedione and monocyclic models. |
University Of Alabama |
2846842 |
14 |
Anticonvulsant activities of phenyl-substituted bicyclic 2,4-oxazolidinediones and monocyclic models. Comparison with binding to the neuronal voltage-dependent sodium channel. |
University Of Alabama |
15177465 |
18 |
2-Alkyl-4-arylimidazoles: structurally novel sodium channel modulators. |
Institut Henri Beaufour |
10406642 |
8 |
Synthesis and preliminary biological evaluation of new alpha-amino amide anticonvulsants incorporating a dextromethorphan moiety. |
Pharmacia & Upjohn |
25927480 |
36 |
Voltage-Gated Sodium Channels: Structure, Function, Pharmacology, and Clinical Indications. |
Merck Research Laboratories |
25026046 |
42 |
Studies examining the relationship between the chemical structure of protoxin II and its activity on voltage gated sodium channels. |
Purdue Pharma |
19388676 |
21 |
Novel, broad-spectrum anticonvulsants containing a sulfamide group: advancement of N-((benzo[b]thien-3-yl)methyl)sulfamide (JNJ-26990990) into human clinical studies. |
Johnson & Johnson Pharmaceutical Research & Development |
9703475 |
19 |
Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents. |
Cambridge Neuroscience |
9685245 |
22 |
Design, synthesis, and pharmacological evaluation of conformationally constrained analogues of N,N'-diaryl- and N-aryl-N-aralkylguanidines as potent inhibitors of neuronal Na+ channels. |
Cambridge Neuroscience |
8295214 |
21 |
Synthesis and pharmacological evaluation of phenylacetamides as sodium-channel blockers. |
Warner-Lambert |
10571163 |
14 |
A novel class of Na+ and Ca2+ channel dual blockers with highly potent anti-ischemic effects. |
Institute For Bio-Medical Research |
10498200 |
40 |
Sodium channel activity and sigma binding of 2-aminopropanamide anticonvulsants. |
Pharmacia & Upjohn |
| 15 |
Batrachotoxin binding site antagonists |
TBA |
21962108 |
14 |
Lactam-stabilized helical analogues of the analgesicµ-conotoxin KIIIA. |
Monash University |
18640044 |
24 |
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist 'CJ-17,493'. |
Pfizer |
17724025 |
8 |
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. |
University Of Utah |
15080972 |
64 |
The design, preparation and SAR of novel small molecule sodium (Na(+)) channel blockers. |
Arqule |
8691482 |
25 |
A structure-activity relationship study of novel phenylacetamides which are sodium channel blockers. |
Warner-Lambert |