The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25911624 |
121 |
Design, synthesis and structure-activity relationship of oxazolidinone derivatives containing novel S4 ligand as FXa inhibitors. |
Shenyang Pharmaceutical University |
25405503 |
109 |
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity. |
Bristol-Myers Squibb |
24405333 |
69 |
Tetrahydroquinoline derivatives as potent and selective factor XIa inhibitors. |
Bristol-Myers Squibb |
20650636 |
118 |
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. |
F. Hoffmann-La Roche |
19231206 |
20 |
Exploration of 4,4-disubstituted pyrrolidine-1,2-dicarboxamides as potent, orally active Factor Xa inhibitors with extended duration of action. |
Pfizer |
19128974 |
28 |
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: a novel, potent and orally active direct inhibitor of factor Xa. |
Daiichi Sankyo |
12643903 |
81 |
Nonbenzamidine isoxazoline derivatives as factor Xa inhibitors. |
Bristol-Myers Squibb |
11266160 |
57 |
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. |
Dupont Pharmaceuticals |
10782664 |
42 |
Isoxazolines and isoxazoles as factor Xa inhibitors. |
Dupont Pharmaceuticals |
9873692 |
54 |
Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa. |
Dupont Pharmaceuticals |