The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28230981 |
37 |
High-Potency Phenylquinoxalinone Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Activators. |
University Of California |
28099811 |
23 |
Nanomolar-Potency Aminophenyl-1,3,5-triazine Activators of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Chloride Channel for Prosecretory Therapy of Dry Eye Diseases. |
University Of California |
26041577 |
13 |
Synthesis and structure-activity relationship of aminoarylthiazole derivatives as correctors of the chloride transport defect in cystic fibrosis. |
Istituto Giannina Gaslini |
25019478 |
13 |
Flavones: an important scaffold for medicinal chemistry. |
Punjabi University |
25452003 |
4 |
¿F508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. |
Wuhan University Of Science And Technology |
25441013 |
49 |
Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator. |
Vertex Pharmaceuticals |
25384240 |
4 |
Discovery heralds new approach to the treatment of cystic fibrosis. |
Jl3Pharma |
24992073 |
2 |
A new 9-alkyladenine-cyclic methylglyoxal diadduct activates wt- and F508del-cystic fibrosis transmembrane conductance regulator (CFTR) in vitro and in vivo. |
Universit£ |
23814642 |
1 |
ABSOLUTE CONFIGURATION AND BIOLOGICAL PROPERTIES OF ENANTIOMERS OF CFTR INHIBITOR BPO-27. |
University Of California |
18077363 |
314 |
A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. |
University Of Oxford |
21707078 |
31 |
Potent, metabolically stable benzopyrimido-pyrrolo-oxazine-dione (BPO) CFTR inhibitors for polycystic kidney disease. |
University Of California |
21397997 |
5 |
An expeditious access to 5-pyrimidinol derivatives from cyclic methylglyoxal diadducts, formation of argpyrimidines under physiological conditions and discovery of new CFTR inhibitors. |
University Joseph Fourier-Grenoble 1/Cnrs |
19785436 |
29 |
Nanomolar potency pyrimido-pyrrolo-quinoxalinedione CFTR inhibitor reduces cyst size in a polycystic kidney disease model. |
University Of California |
18691893 |
43 |
Thiazolidinone CFTR inhibitors with improved water solubility identified by structure-activity analysis. |
University Of California |
18180157 |
10 |
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains. |
St. Jude Children'S Research Hospital |
15808474 |
43 |
Discovery of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid diamides that increase CFTR mediated chloride transport. |
Genzyme |
14761197 |
16 |
Synthesis, SAR, crystal structure, and biological evaluation of benzoquinoliziniums as activators of wild-type and mutant cystic fibrosis transmembrane conductance regulator channels. |
Université |
17157021 |
47 |
Acyclic, orally bioavailable ketone-based cathepsin K inhibitors. |
Gsk |
17941625 |
50 |
Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivity. |
Methylgene |
17552508 |
128 |
Design and Synthesis of Classical and Nonclassical 6-Arylthio-2,4-diamino-5-ethylpyrrolo[2,3-d]pyrimidines as Antifolates. |
Duquesne University |
16963264 |
22 |
Discovery of potent, efficacious, and orally bioavailable inhibitors of blood coagulation factor Xa with neutral P1 moieties. |
Bristol-Myers Squibb Pharmaceutical Research Institute |