The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
25766632 |
31 |
Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2). |
Westf£Lische Wilhelms-Universit£T M£Nster |
20627722 |
89 |
Identification of a sulfonamide series of CCR2 antagonists. |
Glaxosmithkline |
23079519 |
86 |
In vivo activity of an azole series of CCR2 antagonists. |
Glaxosmithkline |
24900425 |
72 |
Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate. |
TBA |
22608963 |
109 |
The design and synthesis of novel, potent and orally bioavailable N-aryl piperazine-1-carboxamide CCR2 antagonists with very high hERG selectivity. |
Astrazeneca |
24900280 |
81 |
Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist. |
TBA |
22475558 |
82 |
Discovery of an orally-bioavailable CC Chemokine Receptor 2 antagonist derived from an acyclic diaminoalcohol backbone. |
Bristol-Myers Squibb |
24900329 |
49 |
Discovery of INCB3284, a Potent, Selective, and Orally Bioavailable hCCR2 Antagonist. |
TBA |
21341682 |
37 |
Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. |
Telik |
21295478 |
81 |
Discovery of INCB10820/PF-4178903, a potent, selective, and orally bioavailable dual CCR2 and CCR5 antagonist. |
Incyte |
21036044 |
43 |
Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2. |
Incyte |
17929797 |
34 |
Synthesis, structure-activity relationship and in vivo antiinflammatory efficacy of substituted dipiperidines as CCR2 antagonists. |
Johnson & Johnson Pharmaceutical Research and Development |
17482462 |
60 |
3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor 2. |
Merck Research Laboratories |
17461566 |
11 |
Discovery of 3-piperidinyl-1-cyclopentanecarboxamide as a novel scaffold for highly potent CC chemokine receptor 2 antagonists. |
Merck Research Laboratories |
17092717 |
59 |
Alpha-aminothiazole-gamma-aminobutanoic amides as potent, small molecule CCR2 receptor antagonists. |
Merck Research Laboratories |