The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 27564419 |
2 |
Synthesis and Antiobesity Properties of 6-(4-Chlorophenyl)-3-(4-((3,3-difluoro-1-hydroxycyclobutyl)methoxy)-3-methoxyphenyl)thieno[3,2-d]pyrimidin-4(3H)-one (BMS-814580): A Highly Efficacious Melanin Concentrating Hormone Receptor 1 (MCHR1) Inhibitor. |
Bristol-Myers Squibb Research & Development |
| 27117261 |
31 |
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel non-basic 1-(2H-indazole-5-yl)pyridin-2(1H)-one derivatives and mitigation of mutagenicity in Ames test. |
Takeda Pharmaceutical |
| 27112449 |
55 |
Amine-free melanin-concentrating hormone receptor 1 antagonists: Novel 1-(1H-benzimidazol-6-yl)pyridin-2(1H)-one derivatives and design to avoid CYP3A4 time-dependent inhibition. |
Takeda Pharmaceutical |
| 26736071 |
79 |
Melanin-Concentrating Hormone Receptor 1 Antagonists Lacking an Aliphatic Amine: Synthesis and Structure-Activity Relationships of Novel 1-(Imidazo[1,2-a]pyridin-6-yl)pyridin-2(1H)-one Derivatives. |
Takeda Pharmaceutical |
| 26386604 |
71 |
Non-basic azolotriazinone MCHR1 antagonists for the treatment of obesity: An empirical brain-exposures-driven candidate selection for in vivo efficacy studies. |
Bristol-Myers Squibb Research and Development |
| 26112443 |
84 |
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part I: Optimization of HTS hits towards an in vivo efficacious tool compound BI 414. |
Boehringer Ingelheim Pharma |
| 26105194 |
24 |
Design, synthesis and evaluation of MCH receptor 1 antagonists--Part III: Discovery of pre-clinical development candidate BI 186908. |
Boehringer Ingelheim Pharma |
| 26022839 |
11 |
Dihydropyrrolopyrazol-6-one MCHR1 antagonists for the treatment of obesity: Insights on in vivo efficacy from a novel FLIPR assay setup. |
Bristol-Myers Squibb Research and Development |
| 22954736 |
2 |
Melanin concentrating hormone receptor 1 (MCHR1) antagonists-Still a viable approach for obesity treatment? |
Leo Pharma |
| 22490048 |
59 |
Synthesis, structure-activity relationship, and pharmacological studies of novel melanin-concentrating hormone receptor 1 antagonists 3-aminomethylquinolines: reducing human ether-a-go-go-related gene (hERG) associated liabilities. |
Takeda Pharmaceutical |
| 22542010 |
31 |
Discovery of a novel melanin concentrating hormone receptor 1 (MCHR1) antagonist with reduced hERG inhibition. |
Amgen |
| 22309223 |
70 |
Melanin-concentrating hormone receptor 1 antagonists. Synthesis and structure-activity relationships of novel 3-(aminomethyl)quinolines. |
Takeda Pharmaceutical |
| 19683441 |
33 |
Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists. |
Tsukuba Research Institute |
| 22019296 |
32 |
Discovery of a novel series of melanin-concentrating hormone receptor 1 antagonists for the treatment of obesity. |
Amgen |
| 21975069 |
65 |
Melanin-concentrating hormone receptor 1 antagonists: synthesis, structure-activity relationship, docking studies, and biological evaluation of 2,3,4,5-tetrahydro-1H-3-benzazepine derivatives. |
Takeda Pharmaceutical |
| 21802292 |
13 |
Strategies to lower the Pgp efflux liability in a series of potent indole azetidine MCHR1 antagonists. |
Lundbeck Research Usa |
| 21856163 |
92 |
Discovery, synthesis, and structure-activity relationship of 6-aminomethyl-7,8-dihydronaphthalenes as human melanin-concentrating hormone receptor 1 antagonists. |
Takeda Pharmaceutical |
| 17668922 |
63 |
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists part 2: A hybrid strategy combining key fragments of HTS hits. |
Lundbeck Research Usa |
| 17668921 |
41 |
Synthesis and SAR investigations for novel melanin-concentrating hormone 1 receptor (MCH1) antagonists Part 1. The discovery of arylacetamides as viable replacements for the dihydropyrimidinone moiety of an HTS hit. |
Lundbeck Research Usa |
| 16919456 |
61 |
2-Aminoquinoline melanin-concentrating hormone (MCH)1R antagonists. |
Merck Research Laboratories |
| 16789729 |
25 |
A thienopyridazinone-based melanin-concentrating hormone receptor 1 antagonist with potent in vivo anorectic properties. |
Neurocrine Biosciences |
| 15615535 |
14 |
A screening library for peptide activated G-protein coupled receptors. 1. The test set. |
Neurocrine Biosciences |
| 26701387 |
16 |
Benzobisthiazoles Represent a Novel Scaffold for Kinase Inhibitors of CLK Family Members. |
University College London |
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