80 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27777011	92	Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases.	Depaul University
26422006	13	Inhibiting the Inflammasome: A Chemical Perspective.	The University of Manchester
26641525	6	Azaphilones from an Acid Mine Extremophile Strain of a Pleurostomophora sp.	Memorial Sloan-Kettering Cancer Center
25418070	2	Electrophilic warhead-based design of compounds preventing NLRP3 inflammasome-dependent pyroptosis.	Universit£
25358116	84	Synthesis of 7-halogenated isatin sulfonamides: nonradioactive counterparts of caspase-3/-7 inhibitor-based potential radiopharmaceuticals for molecular imaging of apoptosis.	Westf£Lische Wilhelms-Universit£T M£Nster
23411396	60	Synthesis of new fluorinated, 2-substituted 5-pyrrolidinylsulfonyl isatin derivatives as caspase-3 and caspase-7 inhibitors: nonradioactive counterparts of putative PET-compatible apoptosis imaging agents.	Westf£Lische Wilhelms-Universit£T M£Nster
24900651	50	Irreversible inhibitors of cysteine proteases.	Dart Neuroscience
22276851	4	Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.	University of Montana
19715320	87	Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation.	University of Florida
16870441	30	Synthesis and evaluation of thiazepines as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter and Gamble Pharmaceuticals
16046125	18	Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1beta synthesis.	Procter & Gamble Pharmaceuticals
10669559	180	Protease inhibitors: current status and future prospects.	University of Queensland
14980679	30	Dipeptidyl aspartyl fluoromethylketones as potent caspase-3 inhibitors: SAR of the P2 amino acid.	Maxim Pharmaceuticals
9873373	20	Peptidyl beta-homo-aspartals: specific inhibitors of interleukin-1 beta converting enzyme and its homologues (caspases).	Institute For Drug Research
21441025	147	Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay.	Washington University
20674352	50	Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.	Pfizer
20656488	61	Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).	Pfizer
20170165	13	Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1.	The University of Queensland
19908842	84	Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.	National Human Genome Research Institute
	25	3-chloro-4-carboxamido-6-arylpyridazines as a non-peptide class of interleukin-1β converting enzyme inhibitor	TBA
	13	Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme	TBA
	32	PYRIDONE-BASED PEPTIDOMIMETIC INHIBITORS OF INTERLEUKIN-1β-CONVERTING ENZYME (ICE)	TBA
	2	Structural and stereochemical requirements of time-dependent inactivators of the interleukin-1β converting enzyme	TBA
	24	Inhibition of interleukin-1β converting enzyme by N-acyl-aspartyl aryloxymethyl ketones	TBA
	16	Inhibition of interleukin-1β converting enzyme by N-Acyl-aspartic acid ketones	TBA
	17	The synthesis and evaluation of peptidyl aspartyl aldehydes as inhibitors of ice.	TBA
	8	Activated ketones as potent reversible inhibitors of interleukin-Iβ converting enzyme	TBA
	2	Synthesis of a peptidyl 2,2-difluoro-4-phenylbutyl ketone and its evaluation as an inhibitor of interleukin-1β converting enzyme.	TBA
	10	Phenylalkyl ketones as potent reversible inhibitors of interleukin-1β converting enzyme	TBA
	1	Synthesis of a potent, reversible inhibitor of interleukin-1β converting enzyme	TBA
19445513	82	Fluorinated isatin derivatives. Part 2. New N-substituted 5-pyrrolidinylsulfonyl isatins as potential tools for molecular imaging of caspases in apoptosis.	Westfalische Wilhelms-Universitat
19049429	70	Design, synthesis, and biological characterization of a caspase 3/7 selective isatin labeled with 2-[18F]fluoroethylazide.	Imperial College
18457385	41	Recent developments in fragment-based drug discovery.	Astex Therapeutics
18330993	4	The berkeleyamides, amides from the acid lake fungus Penicillum rubrum.	Montana Tech of The University of Montana
17889532	23	Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: peptidomimetic replacement of the P(2) amino acid by 2-aminoaryl acids and other non-natural amino acids.	Epicept
17585855	65	Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors.	Washington University
17251019	30	Solid-phase analogue synthesis of caspase-3 inhibitors via palladium-catalyzed amination of 3-bromopyrazinones.	Merck Frosst Centre For Therapeutic Research
17181147	10	Synthesis of novel caspase inhibitors for characterization of the active caspase proteome in vitro and in vivo.	University of Edinburgh
17154501	121	5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis.	University Hospital of The WestfäLische Wilhelms-UniversitäT
17127070	61	Synthesis and evaluation of unsaturated caprolactams as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter & Gamble Pharmaceuticals
16891117	5	Synthesis, radiolabeling, and in vivo evaluation of an 18F-labeled isatin analog for imaging caspase-3 activation in apoptosis.	Washington University
16782334	61	Synthesis and evaluation of novel 1-(2-acylhydrazinocarbonyl)-cycloalkyl carboxamides as interleukin-1beta converting enzyme (ICE) inhibitors.	Procter & Gamble Pharmaceuticals
16274992	29	Tethering identifies fragment that yields potent inhibitors of human caspase-1.	Sunesis Pharmaceuticals
16216507	87	Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1beta converting enzyme inhibitors.	Procter & Gamble Pharmaceuticals
16046129	18	Synthesis and evaluation of tricyclic pyrrolopyrimidinones as dipeptide mimetics: inhibition of interleukin-1beta-converting enzyme.	Procter & Gamble Pharmaceuticals
15686936	210	Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors.	Merck Frosst Centre For Therapeutic Research
15109679	15	Oxamyl dipeptide caspase inhibitors developed for the treatment of stroke.	Idun Pharmaceuticals
14741295	29	The design and synthesis of sulfonamides as caspase-1 inhibitors.	Pfizer
14505683	6	Structure-activity relationships within a series of caspase inhibitors: effect of leaving group modifications.	Idun Pharmaceuticals
12593666	30	Structure-activity relationship study and drug profile of N-(4-fluorophenylsulfonyl)-L-valyl-L-leucinal (SJA6017) as a potent calpain inhibitor.	Senju Pharmaceutical
12270186	99	Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization.	Idun Pharmaceuticals
12270185	257	Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization.	Idun Pharmaceuticals
11934593	1	A practical synthesis of (S) 3-tert-butoxycarbonylamino-2-oxo-2,3,4,5-tetrahydro-1,5-benzodiazepine-1-acetic acid methyl ester as a conformationally restricted dipeptido-mimetic for caspase-1 (ICE) inhibitors.	Vertex Pharmaceuticals
10978183	40	Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery.	Basf Bioresearch
9873617	30	Conformationally constrained inhibitors of caspase-1 (interleukin-1 beta converting enzyme) and of the human CED-3 homologue caspase-3 (CPP32, apopain).	Idun Pharmaceuticals
9873533	11	Rapid optimization of an ICE inhibitor synthesis using multiple reaction conditions in a parallel array.	Warner-Lambert
9873452	1	Novel cytokine release inhibitors. Part I: Triterpenes.	RhóNe-Poulenc Rorer Central Research
9871520	30	Peptidomimetic aminomethylene ketone inhibitors of interleukin-1 beta-converting enzyme (ICE).	Ferring Research Institute
9207934	6	Pyridazinodiazepines as a high-affinity, P2-P3 peptidomimetic class of interleukin-1 beta-converting enzyme inhibitor.	Sanofi Winthrop
29157864	4	New Caspase-1 inhibitor by scaffold hopping into bio-inspired 3D-fragment space.	Edelris
29648825	47	Rational Drug Design of Topically Administered Caspase 1 Inhibitors for the Treatment of Inflammatory Acne.	Nestl�
28238723	39	Non-steroidal Anti-inflammatory Drugs Are Caspase Inhibitors.	University of Colorado
25871734	13	Lazaroids U83836E and U74389G are potent, time-dependent inhibitors of caspase-1.	Depaul University
19326941	104	Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6.	Washington University
11591522	17	Structure-based design of caspase-1 inhibitor containing a diphenyl ether sulfonamide.	Pfizer
11738604	13	Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1).	Pfizer
14741294	72	Discovery of novel aspartyl ketone dipeptides as potent and selective caspase-3 inhibitors.	Merck Frosst Canada
16023344	120	Lipophilic versus hydrogen-bonding effect in P3 on potency and selectivity of valine aspartyl ketones as caspase 3 inhibitors.	Merck Frosst Canada
16302804	145	N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.	Washington University
11384246	86	Potent and selective nonpeptide inhibitors of caspases 3 and 7.	Glaxosmithkline
9829999	2	Inhibition of human caspases by peptide-based and macromolecular inhibitors.	Merck Research Laboratories
12408711	112	Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design.	Sunesis Pharmaceuticals