BDBM13520 (3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one::(R,S)::Diazepanone Analog 19
SMILES: C[C@@H]1N(CCCNC1=O)C(=O)C[C@H](N)Cc1cc(F)c(F)cc1F
InChI Key: InChIKey=SWKGZJAAGSVROJ-GXSJLCMTSA-N
Data: 1 IC50
PDB links: 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM13520![]() ((3S)-4-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)buta...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 150 | n/a | n/a | n/a | n/a | 7.5 | 37 |
Merck Research Laboratories | Assay Description The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m... | Bioorg Med Chem Lett 17: 49-52 (2007) Article DOI: 10.1016/j.bmcl.2006.09.099 BindingDB Entry DOI: 10.7270/Q2F47MC2 | |||||||||||
More data for this Ligand-Target Pair |