BindingDB PrimarySearch

null

SMILES: Nc1ncnc2n(cnc12)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@@](O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O

InChI Key: InChIKey=ZKHQWZAMYRWXGA-KQYNXXCUSA-N

PDB links: 2550 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 56 hits for monomerid = 50366480
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant phospho-MK2 (36-400) by HTRF assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Endoplasmin (Canis familiaris)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	3.24E+3	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					Assay Description Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...				J Med Chem 56: 6803-18 (2013) Article DOI: 10.1021/jm400619b BindingDB Entry DOI: 10.7270/Q2PN972K
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	6.30E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [8-3H]ATP from human recombinant MK2 (36-400) by scintillation proximity assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [8-3H]ATP from human recombinant MK2 (41-364) by scintillation proximity assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair
Heat shock protein 75 kDa, mitochondrial (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	3.13E+4	n/a	n/a	n/a	n/a	n/a	n/a
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					Assay Description Displacement of 5-(3-(3-(6-amino-8-(6-iodobenzo[d][1,3]dioxol-5-ylthio)-9H-purin-9-yl)propyl)thioureido)-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic a...				J Med Chem 56: 6803-18 (2013) Article DOI: 10.1021/jm400619b BindingDB Entry DOI: 10.7270/Q2PN972K
Memorial Sloan-Kettering Cancer Center Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 12 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	2.51E+5	n/a	n/a	n/a	n/a	n/a	n/a
Galecto Biotech Curated by ChEMBL					Assay Description Antagonist activity at P2Y12 receptor in human platelets assessed as inhibition of ADP-induced platelet aggregation by turbidimetric method				Bioorg Med Chem Lett 26: 2739-2754 (2016) Article DOI: 10.1016/j.bmcl.2016.04.030 BindingDB Entry DOI: 10.7270/Q2FF3V86
Galecto Biotech Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate kinase isoenzyme 1 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	5.70E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against rat Adenylate kinase M isoenzyme in the presence of ATP non competitive inhibition				J Med Chem 25: 1179-84 (1983) BindingDB Entry DOI: 10.7270/Q25D8SD7
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Adenylate kinase 2, mitochondrial (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	9.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Inhibitory activity against rat adenylate kinase II was determined in the presence of ATP, non competitive inhibition				J Med Chem 25: 1179-84 (1983) BindingDB Entry DOI: 10.7270/Q25D8SD7
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 1 (Meleagris gallopavo)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.35E+3	n/a	n/a	n/a	n/a
Bar-Ilan University Curated by ChEMBL					Assay Description Agonistic activity for P2Y purinoceptor 1 of turkey erythrocyte membranes				J Med Chem 42: 3636-46 (1999) Article DOI: 10.1021/jm990158y BindingDB Entry DOI: 10.7270/Q2G73FD8
Bar-Ilan University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 2				J Med Chem 45: 2090-100 (2002) BindingDB Entry DOI: 10.7270/Q25H7GZB
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 1 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Accumulation of inositol phosphate in 1321N1 astrocytoma cells expressing human P2Y1 purinoceptor				J Med Chem 45: 2090-100 (2002) BindingDB Entry DOI: 10.7270/Q25H7GZB
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 1 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Activation of Purinoceptor P2Y1-mediated phospholipase C in turkey erythrocyte membranes				J Med Chem 45: 2090-100 (2002) BindingDB Entry DOI: 10.7270/Q25H7GZB
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 11 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.73E+4	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Agonist activity by measuring inositol phosphate accumulation in 1321N1 human astrocytoma cells stably expressing human P2Y purinoceptor 11				J Med Chem 45: 2090-100 (2002) BindingDB Entry DOI: 10.7270/Q25H7GZB
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 2 (P2Y2)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 11 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.70E+4	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against phospholipase C coupled human P2Y purinoceptor 11 (P2Y11)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Antagonist activity against recombinant human P2X purinoceptor 4 (P2X4)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 5 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Antagonist activity against recombinant rat P2X purinoceptor 5 (P2X5)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 2 (RAT)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.40E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against recombinant rat receptor P2X purinoceptor 2 (P2X2) at 10 uM, expressed in Xenopus oocytes				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (RAT)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 4 (P2X4) 3 uM				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 6 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Antagonist activity against recombinant rat P2X purinoceptor 6 (P2X6 )				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 4 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	4.30E+4	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 4 (P2Y4)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 6 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for agonist activity against phospholipase C coupled recombinant human P2Y purinoceptor 6 (P2Y6)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 1 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	56	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against recombinant human P2X purinoceptor 1 (P2X1 )				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 4 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	1.80E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for agonist activity against phospholipase C coupled recombinant rat P2Y purinoceptor 4 (P2Y4)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 12 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PubMed	n/a	n/a	n/a	n/a	3.19E+3	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description Antagonist activity against phospholipase C coupled rat P2Y purinoceptor 12 (P2Y12)				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 3 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB PubMed	n/a	n/a	n/a	n/a	340	n/a	n/a	n/a	n/a
National Institute of Diabetes Curated by ChEMBL					Assay Description The compound was evaluated for antagonist activity against recombinant rat P2X purinoceptor 3 (P2X3) at 10 uM, expressed in Xenopus oocytes				J Med Chem 45: 4057-93 (2002) BindingDB Entry DOI: 10.7270/Q2VX0H71
National Institute of Diabetes Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
P2Y purinoceptor 1 (Rattus norvegicus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
Bar-Ilan University Curated by ChEMBL					Assay Description Agonist activity at rat P2Y1R expressed in HEK293 cells assessed as release of intracellular calcium by fluorescence based assay				J Med Chem 55: 7623-35 (2012) Article DOI: 10.1021/jm3006355 BindingDB Entry DOI: 10.7270/Q2KK9CXT
Bar-Ilan University Curated by ChEMBL					More data for this Ligand-Target Pair
Endoplasmin (Canis familiaris)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.90E+4	n/a	n/a	n/a	n/a
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of BODIPY-AG binding to dog Grp94				J Med Chem 49: 4606-15 (2006) Article DOI: 10.1021/jm0603116 BindingDB Entry DOI: 10.7270/Q2RX9CWC
Infinity Pharmaceuticals, Inc. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
2-dehydropantoate 2-reductase (Escherichia coli (strain K12))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	6.10E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University Chemical Laboratory Curated by ChEMBL					Assay Description Inhibition of Escherichia coli KPR				J Med Chem 49: 4992-5000 (2006) Article DOI: 10.1021/jm060490r BindingDB Entry DOI: 10.7270/Q28S4QQN
University Chemical Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
2-dehydropantoate 2-reductase (Escherichia coli (strain K12))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	1.30E+5	n/a	n/a	n/a	n/a	n/a
University Chemical Laboratory Curated by ChEMBL					Assay Description Binding affinity to Escherichia coli KPR				J Med Chem 49: 4992-5000 (2006) Article DOI: 10.1021/jm060490r BindingDB Entry DOI: 10.7270/Q28S4QQN
University Chemical Laboratory Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	85	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C				J Med Chem 50: 1166-76 (2007) Article DOI: 10.1021/jm060903o BindingDB Entry DOI: 10.7270/Q2PK0GZ1
					More data for this Ligand-Target Pair
P2Y purinoceptor 11 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	6.70E+3	n/a	n/a	n/a	n/a
Bar-Ilan University Curated by ChEMBL					Assay Description Agonist activity at human GFP-tagged P2Y11R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresc...				J Med Chem 56: 4938-52 (2013) Article DOI: 10.1021/jm400197m BindingDB Entry DOI: 10.7270/Q2Q52R0Q
Bar-Ilan University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 1 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	850	n/a	n/a	n/a	n/a
Bar-Ilan University Curated by ChEMBL					Assay Description Agonist activity at human GFP-tagged P2Y1R transfected in human 1321N1 cells assessed as induction of intracellular calcium mobilization by fluoresce...				J Med Chem 56: 4938-52 (2013) Article DOI: 10.1021/jm400197m BindingDB Entry DOI: 10.7270/Q2Q52R0Q
Bar-Ilan University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	95.8	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at N-terminal HA epitope-tagged wild type 3 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellula...				J Med Chem 52: 2762-75 (2009) Article DOI: 10.1021/jm801442p BindingDB Entry DOI: 10.7270/Q2QC04FD
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	63.1	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellula...				J Med Chem 52: 2762-75 (2009) Article DOI: 10.1021/jm801442p BindingDB Entry DOI: 10.7270/Q2QC04FD
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Mus musculus)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Antagonist activity at mouse P2X4 receptor by cell-based calcium influx assay				J Med Chem 55: 9576-88 (2012) Article DOI: 10.1021/jm300845v BindingDB Entry DOI: 10.7270/Q2XK8GPN
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (RAT)	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Antagonist activity at rat P2X4 receptor by cell-based calcium influx assay				J Med Chem 55: 9576-88 (2012) Article DOI: 10.1021/jm300845v BindingDB Entry DOI: 10.7270/Q2XK8GPN
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
P2X purinoceptor 4 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Bonn Curated by ChEMBL					Assay Description Antagonist activity at human P2X4 receptor expressed in 1321N1 cells assessed as inhibition of ATP-induced cytosolic calcium influx compound preincub...				J Med Chem 55: 9576-88 (2012) Article DOI: 10.1021/jm300845v BindingDB Entry DOI: 10.7270/Q2XK8GPN
University of Bonn Curated by ChEMBL					More data for this Ligand-Target Pair
Mitogen-activated protein kinase kinase kinase 7 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	2.80E+3	n/a	n/a	n/a	n/a	n/a
Chugai Pharmaceutical Co., Ltd. Curated by ChEMBL					Assay Description In vitro 100 nM cortex affinity to displace [3H]- -pirenzepine providing a measure of muscarinic m1 receptor antagonist affinity				Bioorg Med Chem Lett 27: 1031-1036 (2017) Article DOI: 10.1016/j.bmcl.2016.12.064 BindingDB Entry DOI: 10.7270/Q22J6F3R
Chugai Pharmaceutical Co., Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at P2Y2 receptor in human CF/T43 cells				Bioorg Med Chem 26: 366-375 (2018) Article DOI: 10.1016/j.bmc.2017.11.043 BindingDB Entry DOI: 10.7270/Q2NZ8B61
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at P2Y2 receptor (unknown origin)				Bioorg Med Chem 26: 366-375 (2018) Article DOI: 10.1016/j.bmc.2017.11.043 BindingDB Entry DOI: 10.7270/Q2NZ8B61
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	180	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at P2Y2 receptor in NG108-15 cells (unknown origin)				Bioorg Med Chem 26: 366-375 (2018) Article DOI: 10.1016/j.bmc.2017.11.043 BindingDB Entry DOI: 10.7270/Q2NZ8B61
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	200	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Agonist activity at P2Y2 receptor in BEA cells (unknown origin)				Bioorg Med Chem 26: 366-375 (2018) Article DOI: 10.1016/j.bmc.2017.11.043 BindingDB Entry DOI: 10.7270/Q2NZ8B61
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	69	n/a	n/a	n/a	n/a	n/a
Harvard University Curated by ChEMBL					Assay Description Binding affinity against Purine Nucleoside Phosphatase				J Med Chem 45: 2770-80 (2002) Article DOI: 10.1021/jm0105833 BindingDB Entry DOI: 10.7270/Q2MG7S8S
Harvard University Curated by ChEMBL					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Binding affinity to 6XHis-tagged human JAK2 JH2 domain V617F mutant (513 to 827 residues) expressed in baculovirus infected Sf9 cells by MANT-ATP bin...				J Med Chem 63: 5324-5340 (2020) Article DOI: 10.1021/acs.jmedchem.0c00192 BindingDB Entry DOI: 10.7270/Q2MW2MH3
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a	n/a
Yale University Curated by ChEMBL					Assay Description Binding affinity to wild type 6XHis-tagged human JAK2 JH2 domain (513 to 827 residues) expressed in baculovirus infected Sf9 cells by MANT-ATP bindin...				J Med Chem 63: 5324-5340 (2020) Article DOI: 10.1021/acs.jmedchem.0c00192 BindingDB Entry DOI: 10.7270/Q2MW2MH3
Yale University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
CDGSH iron-sulfur domain-containing protein 1 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars		n/a	n/a	n/a	1.92E+3	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
P2Y purinoceptor 2 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars		n/a	n/a	n/a	n/a	230	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
P2Y purinoceptor 4 (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars		n/a	n/a	n/a	n/a	6.20E+3	n/a	n/a	n/a	n/a
TBA									Citation and Details
TBA					More data for this Ligand-Target Pair
Glycerol kinase (Homo sapiens (Human))	BDBM50366480 (ADENOSINE TRIPHOSPHATE \| ATP) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase MCE KEGG MMDB PC cid PC sid PDB UniChem Similars	Article	2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Tested for its binding affinity against glycerol kinase (ATP competitive inhibition)				Bioorg Med Chem Lett 7: 2613-2616 (1997) Article DOI: 10.1016/S0960-894X(97)10051-8 BindingDB Entry DOI: 10.7270/Q2GF0V0S
TBA Curated by ChEMBL					More data for this Ligand-Target Pair

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