BDBM10094 (3Z)-5-fluoro-4-iodo-3-[(3-methoxy-1H-pyrrol-2-yl)methylidene]-2,3-dihydro-1H-indol-2-one::oxindole inhibitor 6

SMILES: COc1cc[nH]c1\C=C1/C(=O)Nc2ccc(F)c(I)c12

InChI Key: InChIKey=JTWFHXHESYOBSQ-SREVYHEPSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 10094   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
CDK2/CycE (Homo sapiens (Human))	BDBM10094 ((3Z)-5-fluoro-4-iodo-3-[(3-methoxy-1H-pyrrol-2-yl)...) Show SMILES COc1cc[nH]c1\C=C1/C(=O)Nc2ccc(F)c(I)c12 Show InChI InChI=1S/C14H10FIN2O2/c1-20-11-4-5-17-10(11)6-7-12-9(18-14(7)19)3-2-8(15)13(12)16/h2-6,17H,1H3,(H,18,19)/b7-6-	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	7.5	22
Hoffmann-La Roche Inc.					Assay Description Kinase assays were performed using a recombinant human cyclin E-CDK2 complex. The enzyme was assayed with substrate in the presence of 1uM ATP/[gamma...				Bioorg Med Chem Lett 14: 913-7 (2004) Article DOI: 10.1016/j.bmcl.2003.12.009 BindingDB Entry DOI: 10.7270/Q20V8B1V
					More data for this Ligand-Target Pair