BDBM102510 US8536175, 24

SMILES: COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c2nccnc12

InChI Key: InChIKey=UWEXSNHIQLDQQH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102510 (US8536175, 24) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c2nccnc12 |(6.55,4,;7.32,2.67,;6.55,1.33,;7.31,,;6.55,-1.33,;7.32,-2.67,;8.86,-2.67,;5.01,-1.33,;4.23,-2.67,;4.23,,;5.01,1.33,;4.23,2.67,;2.69,,;1.93,1.33,;.38,1.33,;-.38,,;-1.92,,;-2.69,1.33,;-2.69,-1.33,;-4.23,-1.33,;-5,,;-6.54,,;-7.31,-1.33,;-8.85,-1.33,;-6.54,-2.67,;-5,-2.67,;.38,-1.33,;-.38,-2.67,;.38,-4,;1.93,-4,;2.69,-2.67,;1.93,-1.33,)| Show InChI InChI=1S/C22H16Cl2N4O4/c1-31-14-9-15(32-2)19(24)17(18(14)23)12-4-5-13(21-20(12)25-7-8-26-21)22(30)28-11-3-6-16(29)27-10-11/h3-10H,1-2H3,(H,27,29)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102510 (US8536175, 24) Show SMILES COc1cc(OC)c(Cl)c(c1Cl)-c1ccc(C(=O)Nc2ccc(=O)[nH]c2)c2nccnc12 |(6.55,4,;7.32,2.67,;6.55,1.33,;7.31,,;6.55,-1.33,;7.32,-2.67,;8.86,-2.67,;5.01,-1.33,;4.23,-2.67,;4.23,,;5.01,1.33,;4.23,2.67,;2.69,,;1.93,1.33,;.38,1.33,;-.38,,;-1.92,,;-2.69,1.33,;-2.69,-1.33,;-4.23,-1.33,;-5,,;-6.54,,;-7.31,-1.33,;-8.85,-1.33,;-6.54,-2.67,;-5,-2.67,;.38,-1.33,;-.38,-2.67,;.38,-4,;1.93,-4,;2.69,-2.67,;1.93,-1.33,)| Show InChI InChI=1S/C22H16Cl2N4O4/c1-31-14-9-15(32-2)19(24)17(18(14)23)12-4-5-13(21-20(12)25-7-8-26-21)22(30)28-11-3-6-16(29)27-10-11/h3-10H,1-2H3,(H,27,29)(H,28,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	530	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair