BDBM102520 US8536175, 115::US8815901, 77

SMILES: CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4c(C)cccc4C)c4nccnc34)[nH]2)CC1

InChI Key: InChIKey=BBYJPZCAQVIXOP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 102520   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102520 (US8536175, 115 | US8815901, 77) Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4c(C)cccc4C)c4nccnc34)[nH]2)CC1 |(-10.29,.87,;-8.96,.1,;-7.63,.87,;-6.29,.1,;-6.29,-1.44,;-4.96,-2.21,;-3.63,-1.44,;-3.63,.1,;-2.16,.58,;-1.26,-.67,;.28,-.67,;1.05,.67,;.28,2,;2.59,.67,;3.36,2,;4.9,2,;5.67,.67,;7.21,.67,;7.98,2,;7.21,3.33,;9.52,2,;10.29,.67,;9.52,-.67,;7.98,-.67,;7.21,-2,;4.9,-.67,;5.67,-2,;4.9,-3.33,;3.36,-3.33,;2.59,-2,;3.36,-.67,;-2.16,-1.91,;-7.63,-2.21,;-8.96,-1.44,)| Show InChI InChI=1S/C26H29N7O/c1-17-5-4-6-18(2)22(17)20-7-8-21(24-23(20)27-9-10-28-24)25(34)31-26-29-15-19(30-26)16-33-13-11-32(3)12-14-33/h4-10,15H,11-14,16H2,1-3H3,(H2,29,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description The assay has been run at room temperature on a liquid handling robot. To the assay plates containing 50 mL compound or control solutions, 4.5 uL of ...				US Patent US8815901 (2014) BindingDB Entry DOI: 10.7270/Q2XG9PT8
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM102520 (US8536175, 115 | US8815901, 77) Show SMILES CN1CCN(Cc2cnc(NC(=O)c3ccc(-c4c(C)cccc4C)c4nccnc34)[nH]2)CC1 |(-10.29,.87,;-8.96,.1,;-7.63,.87,;-6.29,.1,;-6.29,-1.44,;-4.96,-2.21,;-3.63,-1.44,;-3.63,.1,;-2.16,.58,;-1.26,-.67,;.28,-.67,;1.05,.67,;.28,2,;2.59,.67,;3.36,2,;4.9,2,;5.67,.67,;7.21,.67,;7.98,2,;7.21,3.33,;9.52,2,;10.29,.67,;9.52,-.67,;7.98,-.67,;7.21,-2,;4.9,-.67,;5.67,-2,;4.9,-3.33,;3.36,-3.33,;2.59,-2,;3.36,-.67,;-2.16,-1.91,;-7.63,-2.21,;-8.96,-1.44,)| Show InChI InChI=1S/C26H29N7O/c1-17-5-4-6-18(2)22(17)20-7-8-21(24-23(20)27-9-10-28-24)25(34)31-26-29-15-19(30-26)16-33-13-11-32(3)12-14-33/h4-10,15H,11-14,16H2,1-3H3,(H2,29,30,31,34)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description Protein kinase activity measured by the microfluidic caliper method.				US Patent US8536175 (2013) BindingDB Entry DOI: 10.7270/Q27D2SSH
					More data for this Ligand-Target Pair