BDBM112078 US8623889, 76

SMILES: Fc1ccc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c(c1)C#N

InChI Key: InChIKey=GZIGYNCFUJQPKH-UHFFFAOYSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 112078   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase ABL1 (Homo sapiens (Human))	BDBM112078 (US8623889, 76) Show SMILES Fc1ccc(-c2ccc3cc(NC(=O)C4CC4)ncc3c2)c(c1)C#N Show InChI InChI=1S/C20H14FN3O/c21-17-5-6-18(15(8-17)10-22)14-4-3-13-9-19(23-11-16(13)7-14)24-20(25)12-1-2-12/h3-9,11-12H,1-2H2,(H,23,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	0.0600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Genentech, Inc. US Patent					Assay Description Using the following procedure, varying concentration of compounds of the invention were assessed for their ability to inhibit c-Abl enzyme's phos...				US Patent US8623889 (2014) BindingDB Entry DOI: 10.7270/Q2JQ0ZNX
					More data for this Ligand-Target Pair