BDBM11643 (2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-prop-1-ynylpyrrolidine-2-carbonitrile::(2S,5R)-1-[(2S)-2-amino-2-cyclopentylacetyl]-5-(prop-1-yn-1-yl)pyrrolidine-2-carbonitrile::C5-substituted pyrrolidine 19::alkynyl cyanopyrrolidine 2
SMILES: CC#C[C@H]1CC[C@@H](C#N)N1C(=O)[C@@H](N)C1CCCC1
InChI Key: InChIKey=UXJJEQMBADTCCT-IHRRRGAJSA-N
Data: 4 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11643![]() ((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 24 | -10.3 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The DPP4 activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and mea... | J Med Chem 49: 6416-20 (2006) Article DOI: 10.1021/jm060777o BindingDB Entry DOI: 10.7270/Q2M043M1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase 4 (Homo sapiens (Human)) | BDBM11643![]() ((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 30 | -10.2 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas... | Biochemistry 45: 7474-82 (2006) Article DOI: 10.1021/bi060184f BindingDB Entry DOI: 10.7270/Q2P26WCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase IV (Rattus norvegicus (rat)) | BDBM11643![]() ((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | 56 | -9.79 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas... | Biochemistry 45: 7474-82 (2006) Article DOI: 10.1021/bi060184f BindingDB Entry DOI: 10.7270/Q2P26WCG | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dipeptidyl peptidase VIII (Homo sapiens (Human)) | BDBM11643![]() ((2S,5R)-1-((2S)-2-amino-2-cyclopentylethanoyl)-5-p...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | >3.00E+4 | >-6.10 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The DPP activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 355 nm and meas... | Biochemistry 45: 7474-82 (2006) Article DOI: 10.1021/bi060184f BindingDB Entry DOI: 10.7270/Q2P26WCG | |||||||||||
More data for this Ligand-Target Pair |