BDBM118208 US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridin-4- yl)ethynyl)-4H-chromen-3-yl)phenyl)methanesulfonamide
SMILES: CS(=O)(=O)Nc1ccc(cc1)-c1coc2cc(ccc2c1=O)C#Cc1cc[nH]c(=O)c1
InChI Key: InChIKey=SDXFGKHDKBQKRY-UHFFFAOYSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aldehyde dehydrogenase, mitochondrial (Homo sapiens (Human)) | BDBM118208 (US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 9 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description Standard ALDH2 reaction mixtures contained 150 uM formaldehyde, 2.5 mM NAD+, 10 mM MgCl2 and 10 nM recombinant human ALDH2 in 50 mM Hepes buffer, pH ... | US Patent US8673966 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28MX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase [flavin-containing] B (Homo sapiens (Human)) | BDBM118208 (US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US8673966 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28MX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Amine oxidase (flavin-containing) A (Homo sapiens (Human)) | BDBM118208 (US8673966, N-(4-(4-oxo-7-((2-oxo-1,2-dihydropyridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >1.30E+5 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Gilead Sciences, Inc. US Patent | Assay Description MAO assays included luminogenic MAO substrate, reaction buffers, Luciferin Detection and the reconstitution buffer with esterase. Standard MAO reacti... | US Patent US8673966 (2014) BindingDB Entry DOI: 10.7270/Q2QZ28MX | |||||||||||
More data for this Ligand-Target Pair |