BDBM143512 US8969341, 127
SMILES: COc1ccc(CNC(C)=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C
InChI Key: InChIKey=WHEWAAXRLULZDS-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MDM2-MDMX (Homo sapiens (Human)) | BDBM143512 (US8969341, 127) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.196 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis AG US Patent | Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe... | US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8 | |||||||||||
More data for this Ligand-Target Pair |