BDBM143512 US8969341, 127

SMILES: COc1ccc(CNC(C)=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C

InChI Key: InChIKey=WHEWAAXRLULZDS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 143512   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
MDM2-MDMX (Homo sapiens (Human))	BDBM143512 (US8969341, 127) Show SMILES COc1ccc(CNC(C)=O)cc1-n1nc2C(=O)N(C(c2c1C(C)C)c1ccc(Cl)cc1C)c1cc(Cl)ccc1C Show InChI InChI=1S/C32H32Cl2N4O3/c1-17(2)30-28-29(36-38(30)26-14-21(16-35-20(5)39)8-12-27(26)41-6)32(40)37(25-15-23(34)9-7-18(25)3)31(28)24-11-10-22(33)13-19(24)4/h7-15,17,31H,16H2,1-6H3,(H,35,39)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.196	n/a	n/a	n/a	n/a	n/a	n/a
Novartis AG US Patent					Assay Description The inhibition of p53-MDM2 and p53-MDM4 interactions is measured by time resolved fluorescence energy transfer (TR-FRET). Fluorescence energy transfe...				US Patent US8969341 (2015) BindingDB Entry DOI: 10.7270/Q2K35SC8
					More data for this Ligand-Target Pair