BDBM14780 Pyrazole carboxylic ester 3::ethyl 3-methyl-1H-pyrazole-4-carboxylate
SMILES: CCOC(=O)c1cn[nH]c1C
InChI Key: InChIKey=HHYVTIKYZUMDIL-UHFFFAOYSA-N
Data: 2 IC50
PDB links: 7 PDB IDs contain this monomer as substructures. 7 PDB IDs contain inhibitors having a similarity of 90% to this monomer.
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 4 (PDE4D) (Homo sapiens (Human)) | BDBM14780![]() (Pyrazole carboxylic ester 3 | ethyl 3-methyl-1H-py...) | PDB MMDB B.MOAD GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Nat Biotechnol 23: 201-7 (2005) Article DOI: 10.1038/nbt1059 BindingDB Entry DOI: 10.7270/Q21N7ZCN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 4 (PDE4B) (Homo sapiens (Human)) | BDBM14780![]() (Pyrazole carboxylic ester 3 | ethyl 3-methyl-1H-py...) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet ![]() | Purchase PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Nat Biotechnol 23: 201-7 (2005) Article DOI: 10.1038/nbt1059 BindingDB Entry DOI: 10.7270/Q21N7ZCN | |||||||||||
More data for this Ligand-Target Pair |