BDBM150992 US8987257, 5

SMILES: C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1

InChI Key: InChIKey=GPADWYAIKTYMTC-VLFBTDHHSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150992   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human))	BDBM150992 (US8987257, 5) Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-13-12-33-11-10-32(13)20-16-19(29-21(30-20)31-8-4-22(23,24)5-9-31)28-18(27-16)15-3-7-26-17-14(15)2-6-25-17/h2-3,6-7,13H,4-5,8-12H2,1H3/b18-15-/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>9.10E+3	n/a	n/a	n/a	n/a	7.5	4
Novartis AG US Patent					Assay Description PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM150992 (US8987257, 5) Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-13-12-33-11-10-32(13)20-16-19(29-21(30-20)31-8-4-22(23,24)5-9-31)28-18(27-16)15-3-7-26-17-14(15)2-6-25-17/h2-3,6-7,13H,4-5,8-12H2,1H3/b18-15-/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair