Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase mTOR' and Ligand = 'BDBM150992'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase mTOR (Homo sapiens (Human))	BDBM150992 (US8987257, 5) Show SMILES C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1ccnc2[nH]ccc12)N1CCC(F)(F)CC1 |r| Show InChI InChI=1S/C22H22F2N8O/c1-13-12-33-11-10-32(13)20-16-19(29-21(30-20)31-8-4-22(23,24)5-9-31)28-18(27-16)15-3-7-26-17-14(15)2-6-25-17/h2-3,6-7,13H,4-5,8-12H2,1H3/b18-15-/t13-/m0/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	150	n/a	n/a	n/a	n/a	7.5	25
Novartis AG US Patent					Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...				US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B
					More data for this Ligand-Target Pair