BDBM151000 US8987257, 13
SMILES: C[C@H]1COCCN1c1nc(nc2[nH]c(nc12)-c1cnc2cc[nH]c2c1)N1CCOCC1
InChI Key: InChIKey=VZRNGDWQUFNMID-SUXRJGGNSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Homo sapiens (Human)) | BDBM151000 (US8987257, 13) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 430 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Novartis AG US Patent | Assay Description PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS... | US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase mTOR (Homo sapiens (Human)) | BDBM151000 (US8987257, 13) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 469 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Novartis AG US Patent | Assay Description IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a... | US Patent US8987257 (2015) BindingDB Entry DOI: 10.7270/Q2S75F2B | |||||||||||
More data for this Ligand-Target Pair |