BDBM15910 4-Amino-6-(2,5-dimethoxy-benzylamino)-2-ethoxy-nicotinonitrile::4-amino-6-{[(2,5-dimethoxyphenyl)methyl]amino}-2-ethoxypyridine-3-carbonitrile::aminopyridine deriv. 6

SMILES: CCOc1nc(NCc2cc(OC)ccc2OC)cc(N)c1C#N

InChI Key: InChIKey=JIQIVSONTICDKE-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 15910   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM15910 (4-Amino-6-(2,5-dimethoxy-benzylamino)-2-ethoxy-nic...) Show SMILES CCOc1nc(NCc2cc(OC)ccc2OC)cc(N)c1C#N Show InChI InChI=1S/C17H20N4O3/c1-4-24-17-13(9-18)14(19)8-16(21-17)20-10-11-7-12(22-2)5-6-15(11)23-3/h5-8H,4,10H2,1-3H3,(H3,19,20,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	7.2	20
Abbott Laboratories					Assay Description In vitro substrate phosphorylation using purified recombinant JNK, was incubated with substrate, and test compounds in the presence of 5uM ATP/ [gamm...				J Med Chem 49: 4455-8 (2006) Article DOI: 10.1021/jm060465l BindingDB Entry DOI: 10.7270/Q2ST7N3W
					More data for this Ligand-Target Pair