BDBM16450 6-[(2-chloro-4-fluorobenzene)sulfonyl]-2,3-dihydropyridazin-3-one::6-phenylsulfonylpyridazin-2H-3-one, 12::Phenyl-Substituted Sulfonylpyridazinone, 8s

SMILES: Fc1ccc(c(Cl)c1)S(=O)(=O)c1ccc(=O)[nH]n1

InChI Key: InChIKey=AFMMZMYEGLGTBX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16450   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Aldose reductase (AR) (Homo sapiens (Human))	BDBM16450 (6-[(2-chloro-4-fluorobenzene)sulfonyl]-2,3-dihydro...) Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)c1ccc(=O)[nH]n1 Show InChI InChI=1S/C10H6ClFN2O3S/c11-7-5-6(12)1-2-8(7)18(16,17)10-4-3-9(15)13-14-10/h1-5H,(H,13,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.0	24
Pfizer					Assay Description The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...				J Med Chem 46: 2283-6 (2003) Article DOI: 10.1021/jm034065z BindingDB Entry DOI: 10.7270/Q2NV9GGM
					More data for this Ligand-Target Pair
Aldose reductase (AR) (Homo sapiens (Human))	BDBM16450 (6-[(2-chloro-4-fluorobenzene)sulfonyl]-2,3-dihydro...) Show SMILES Fc1ccc(c(Cl)c1)S(=O)(=O)c1ccc(=O)[nH]n1 Show InChI InChI=1S/C10H6ClFN2O3S/c11-7-5-6(12)1-2-8(7)18(16,17)10-4-3-9(15)13-14-10/h1-5H,(H,13,15)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	280	n/a	n/a	n/a	n/a	7.0	24
Pfizer					Assay Description The activity of the enzyme was determined spectrophotometrically by monitoring the change in absorbance at 340 nm, which is due to the disappearance ...				J Med Chem 48: 6326-39 (2005) Article DOI: 10.1021/jm050462t BindingDB Entry DOI: 10.7270/Q2RN363Z
					More data for this Ligand-Target Pair