BDBM174939 US9096593, P-2034

SMILES: COc1cnc2[nH]cc(Cc3ccc(NCc4ccccc4Cl)nc3F)c2c1

InChI Key: InChIKey=FKCBVQDDLMFVAU-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 174939   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM174939 (US9096593, P-2034) Show SMILES COc1cnc2[nH]cc(Cc3ccc(NCc4ccccc4Cl)nc3F)c2c1 Show InChI InChI=1S/C21H18ClFN4O/c1-28-16-9-17-15(11-25-21(17)26-12-16)8-13-6-7-19(27-20(13)23)24-10-14-4-2-3-5-18(14)22/h2-7,9,11-12H,8,10H2,1H3,(H,24,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	25
Plexxikon Inc. US Patent					Assay Description In one assay the biochemical activity IC50 values are determined with respect to inhibition of Flt-3 kinase activity, where inhibition of phosphoryla...				US Patent US9096593 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DXR
					More data for this Ligand-Target Pair
Macrophage colony stimulating factor receptor (Homo sapiens (Human))	BDBM174939 (US9096593, P-2034) Show SMILES COc1cnc2[nH]cc(Cc3ccc(NCc4ccccc4Cl)nc3F)c2c1 Show InChI InChI=1S/C21H18ClFN4O/c1-28-16-9-17-15(11-25-21(17)26-12-16)8-13-6-7-19(27-20(13)23)24-10-14-4-2-3-5-18(14)22/h2-7,9,11-12H,8,10H2,1H3,(H,24,27)(H,25,26)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	30
Plexxikon Inc. US Patent					Assay Description In one assay the biochemical activity IC50 values are determined with respect to inhibition of Fms kinase activity, where inhibition of phosphorylati...				US Patent US9096593 (2015) BindingDB Entry DOI: 10.7270/Q2PK0DXR
					More data for this Ligand-Target Pair