BDBM182462 US9145392, 163

SMILES: CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)-c1ccc(F)c(C)c1

InChI Key: InChIKey=NUPWMMJWFAYJED-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 182462   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human))	BDBM182462 (US9145392, 163) Show SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C26H32FN9/c1-17-12-19(4-5-21(17)27)22-15-36(11-10-34(2)3)25(33-22)18-6-8-35(9-7-18)26-23(20-13-31-32-14-20)24(28)29-16-30-26/h4-5,12-16,18H,6-11H2,1-3H3,(H,31,32)(H2,28,29,30)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.80	n/a	n/a	n/a	n/a	7.5	n/a
Merck Patent GmbH US Patent					Assay Description A TTP Mosquito liquid handling instrument is used to place 125n1 of the appropriate concentration of inhibitor in 100% DMSO (for a dose response curv...				US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2
					More data for this Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K) (Homo sapiens (Human))	BDBM182462 (US9145392, 163) Show SMILES CN(C)CCn1cc(nc1C1CCN(CC1)c1ncnc(N)c1-c1cn[nH]c1)-c1ccc(F)c(C)c1 Show InChI InChI=1S/C26H32FN9/c1-17-12-19(4-5-21(17)27)22-15-36(11-10-34(2)3)25(33-22)18-6-8-35(9-7-18)26-23(20-13-31-32-14-20)24(28)29-16-30-26/h4-5,12-16,18H,6-11H2,1-3H3,(H,31,32)(H2,28,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.730	n/a	n/a	n/a	n/a	7.5	25
Merck Patent GmbH US Patent					Assay Description P70S6K inhibitor compounds are diluted and plated in 96 well plates. A reaction mixture including the following components is then added to the compo...				US Patent US9145392 (2015) BindingDB Entry DOI: 10.7270/Q2NZ86D2
					More data for this Ligand-Target Pair