null
SMILES: CC1(Cc2nnc(o2)C(=O)c2nc3ccc(cc3s2)-c2ccccc2)NC(=O)N(CC(F)(F)F)C1=O
InChI Key: InChIKey=PDDCYKVRYSZZLF-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Endothelial lipase (Homo sapiens (Human)) | BDBM187291 (US9169240, 31 | US9169240, 38 | US9169240, 40) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50... | US Patent US9169240 (2015) BindingDB Entry DOI: 10.7270/Q2W66JK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelial lipase (Homo sapiens (Human)) | BDBM187291 (US9169240, 31 | US9169240, 38 | US9169240, 40) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | <10 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50... | US Patent US9169240 (2015) BindingDB Entry DOI: 10.7270/Q2W66JK8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Endothelial lipase (Homo sapiens (Human)) | BDBM187291 (US9169240, 31 | US9169240, 38 | US9169240, 40) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 11 | n/a | n/a | n/a | n/a | 8.0 | n/a |
Bristol-Myers Squibb Company US Patent | Assay Description The enzymatic assay was measured using white, opaque 96-well half area plates. Each well contained 60 μL of assay buffer (50 mM HEPES pH 8.0, 50... | US Patent US9169240 (2015) BindingDB Entry DOI: 10.7270/Q2W66JK8 | |||||||||||
More data for this Ligand-Target Pair |