null

SMILES: Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1

InChI Key: InChIKey=XEBBMEXBEQLSSM-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20548   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20548 (4-Oxopyrimidine, 20 | 8-({6-[4-(trifluoromethyl)ph...) Show SMILES Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1 Show InChI InChI=1S/C20H13F3N4O/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(26-11-25-15)28-16-3-1-2-13-6-9-17(24)27-19(13)16/h1-11H,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	62	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3515-27 (2007) Article DOI: 10.1021/jm070190p BindingDB Entry DOI: 10.7270/Q2RN364D
					More data for this Ligand-Target Pair
Transient receptor potential cation channel subfamily V member 1 (Rattus norvegicus (rat))	BDBM20548 (4-Oxopyrimidine, 20 | 8-({6-[4-(trifluoromethyl)ph...) Show SMILES Nc1ccc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1 Show InChI InChI=1S/C20H13F3N4O/c21-20(22,23)14-7-4-12(5-8-14)15-10-18(26-11-25-15)28-16-3-1-2-13-6-9-17(24)27-19(13)16/h1-11H,(H2,24,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3515-27 (2007) Article DOI: 10.1021/jm070190p BindingDB Entry DOI: 10.7270/Q2RN364D
					More data for this Ligand-Target Pair