BDBM20553 4-Oxopyrimidine, 31::8-({6-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}oxy)quinoxalin-2-amine

SMILES: Nc1cnc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1

InChI Key: InChIKey=HAZOQFLLNDJKJA-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 20553   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Vanilloid receptor (Rattus norvegicus (rat))	BDBM20553 (4-Oxopyrimidine, 31 | 8-({6-[4-(trifluoromethyl)ph...) Show SMILES Nc1cnc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1 Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)12-6-4-11(5-7-12)14-8-17(26-10-25-14)28-15-3-1-2-13-18(15)27-16(23)9-24-13/h1-10H,(H2,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3515-27 (2007) Article DOI: 10.1021/jm070190p BindingDB Entry DOI: 10.7270/Q2RN364D
					More data for this Ligand-Target Pair
Vanilloid receptor (Rattus norvegicus (rat))	BDBM20553 (4-Oxopyrimidine, 31 | 8-({6-[4-(trifluoromethyl)ph...) Show SMILES Nc1cnc2cccc(Oc3cc(ncn3)-c3ccc(cc3)C(F)(F)F)c2n1 Show InChI InChI=1S/C19H12F3N5O/c20-19(21,22)12-6-4-11(5-7-12)14-8-17(26-10-25-14)28-15-3-1-2-13-18(15)27-16(23)9-24-13/h1-10H,(H2,23,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	63	n/a	n/a	n/a	n/a	7.4	22
Amgen					Assay Description TRPV1 activities were monitored as a function of cellular uptake of radioactive calcium (45Ca2+). The test compounds were preincubated with TRPV1 exp...				J Med Chem 50: 3515-27 (2007) Article DOI: 10.1021/jm070190p BindingDB Entry DOI: 10.7270/Q2RN364D
					More data for this Ligand-Target Pair