BDBM21944 2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl]-1H-1,2,3,4-tetrazol-1-yl}ethyl N-(5-hydroxypentyl)carbamate::Tetrazole-based compound, 10

SMILES: CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO

InChI Key: InChIKey=JLULZNCWGALFOB-GOSISDBHSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21944   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Ghrelin receptor (Homo sapiens (Human))	BDBM21944 (2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...) Show SMILES CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCCCCO |r| Show InChI InChI=1S/C22H35N7O5/c1-22(2,23)20(31)25-18(16-33-15-17-9-5-3-6-10-17)19-26-27-28-29(19)12-14-34-21(32)24-11-7-4-8-13-30/h3,5-6,9-10,18,30H,4,7-8,11-16,23H2,1-2H3,(H,24,32)(H,25,31)/t18-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	14.6	n/a	n/a	7.2	22
Bristol-Myers Squibb Pharmaceutical Research Institute					Assay Description The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...				J Med Chem 50: 5890-3 (2007) Article DOI: 10.1021/jm7010595 BindingDB Entry DOI: 10.7270/Q24J0CCV
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