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BDBM21945 2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl]-1H-1,2,3,4-tetrazol-1-yl}ethyl N-(4-hydroxybutyl)-N-methylcarbamate::Tetrazole-based compound, 11

SMILES: CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N

InChI Key: InChIKey=TWGBAIZTRVRIAV-GOSISDBHSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 21945   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Ghrelin receptor


(Homo sapiens (Human))
BDBM21945
PNG
(2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...)
Show SMILES CN(CCCCO)C(=O)OCCn1nnnc1[C@@H](COCc1ccccc1)NC(=O)C(C)(C)N |r|
Show InChI InChI=1S/C22H35N7O5/c1-22(2,23)20(31)24-18(16-33-15-17-9-5-4-6-10-17)19-25-26-27-29(19)12-14-34-21(32)28(3)11-7-8-13-30/h4-6,9-10,18,30H,7-8,11-16,23H2,1-3H3,(H,24,31)/t18-/m1/s1
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Similars

Article
PubMed
n/an/an/an/a 3.80n/an/a7.222



Bristol-Myers Squibb Pharmaceutical Research Institute



Assay Description
The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio...


J Med Chem 50: 5890-3 (2007)


Article DOI: 10.1021/jm7010595
BindingDB Entry DOI: 10.7270/Q24J0CCV
More data for this
Ligand-Target Pair