BDBM21950 2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benzyloxy)ethyl]-1H-1,2,3,4-tetrazol-1-yl}ethyl N-[2-(3-hydroxyphenyl)ethyl]carbamate::Tetrazole-based compound, 16
SMILES: CC(C)(N)C(=O)N[C@H](COCc1ccccc1)c1nnnn1CCOC(=O)NCCc1cccc(O)c1
InChI Key: InChIKey=JMKGUEVCWGAJAZ-OAQYLSRUSA-N
Data: 1 EC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Ghrelin receptor (Homo sapiens (Human)) | BDBM21950 (2-{5-[(1S)-1-(2-amino-2-methylpropanamido)-2-(benz...) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 7.90 | n/a | n/a | 7.2 | 22 |
Bristol-Myers Squibb Pharmaceutical Research Institute | Assay Description The functional FLIPR assay was developed from H4 glioma cells in which expression of the endogenous human GHS receptor was enhanced by RAGE-activatio... | J Med Chem 50: 5890-3 (2007) Article DOI: 10.1021/jm7010595 BindingDB Entry DOI: 10.7270/Q24J0CCV | |||||||||||
More data for this Ligand-Target Pair |