BDBM22178 1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2S)-2-methoxy-3-phenylpropyl]piperazine::GBR 12935 Analogue, (S)-9
SMILES: CO[C@H](CN1CCN(CCOC(c2ccc(F)cc2)c2ccc(F)cc2)CC1)Cc1ccccc1
InChI Key: InChIKey=SPVLIWURVCWIKT-NDEPHWFRSA-N
Data: 2 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Sodium-dependent dopamine transporter (Rattus norvegicus (rat)) | BDBM22178 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2S)-2-...) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 29 | -9.55 | n/a | n/a | n/a | n/a | n/a | 7.4 | 4 |
National Taiwan University | Assay Description The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated... | J Med Chem 51: 2795-806 (2008) Article DOI: 10.1021/jm701270n BindingDB Entry DOI: 10.7270/Q2B27SK6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Sodium-dependent serotonin transporter (Rattus norvegicus (rat)) | BDBM22178 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-[(2S)-2-...) | PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
National Taiwan University | Assay Description The assay was initiated by the addition of membranes to binding buffer containing test compound, blocker, and radioligand. The samples were incubated... | J Med Chem 51: 2795-806 (2008) Article DOI: 10.1021/jm701270n BindingDB Entry DOI: 10.7270/Q2B27SK6 | |||||||||||
More data for this Ligand-Target Pair |