BDBM22299 4-pentyl-N-{2-[2-(4-propanoylphenyl)-1H-indol-3-yl]ethyl}benzene-1-sulfonamide::tryptamine sulfonamide, 37i
SMILES: CCCCCc1ccc(cc1)S(=O)(=O)NCCc1c([nH]c2ccccc12)-c1ccc(cc1)C(=O)CC
InChI Key: InChIKey=DMZOJBDTAGOAIV-UHFFFAOYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Arachidonate 15-lipoxygenase (Oryctolagus cuniculus (rabbit)) | BDBM22299 (4-pentyl-N-{2-[2-(4-propanoylphenyl)-1H-indol-3-yl...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Bristol-Myers Squibb Company | Assay Description The inhibitory activity of the compounds against purified 15-LO enzyme was determined using a standard colorimetric assay in which the lipid hydroper... | Bioorg Med Chem Lett 15: 1435-40 (2005) Article DOI: 10.1016/j.bmcl.2004.12.081 BindingDB Entry DOI: 10.7270/Q2T43RD2 | |||||||||||
More data for this Ligand-Target Pair |