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SMILES: CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1

InChI Key: InChIKey=RSJHIJPWHNIXEY-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 224972   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-3


(Homo sapiens (Human))
BDBM224972
PNG
(US9321756, 239)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1
Show InChI InChI=1S/C16H12FN5S/c1-18-16-22-21-15(23-16)9-5-6-12-10(7-9)11(8-19-12)13-3-2-4-14(17)20-13/h2-8,19H,1H3,(H,18,22)
KEGG

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 170n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-2


(Homo sapiens (Human))
BDBM224972
PNG
(US9321756, 239)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1
Show InChI InChI=1S/C16H12FN5S/c1-18-16-22-21-15(23-16)9-5-6-12-10(7-9)11(8-19-12)13-3-2-4-14(17)20-13/h2-8,19H,1H3,(H,18,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 739n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM224972
PNG
(US9321756, 239)
Show SMILES CNc1nnc(s1)-c1ccc2[nH]cc(-c3cccc(F)n3)c2c1
Show InChI InChI=1S/C16H12FN5S/c1-18-16-22-21-15(23-16)9-5-6-12-10(7-9)11(8-19-12)13-3-2-4-14(17)20-13/h2-8,19H,1H3,(H,18,22)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 1.03E+3n/an/an/an/an/an/a



AMGEN INC.

US Patent


Assay Description
The assay for the determination of Pim activity is based on the formation of phosphorylated biotinylated-BAD peptide at the Serine 112 residue (S112)...


US Patent US9321756 (2016)


BindingDB Entry DOI: 10.7270/Q2W094S2
More data for this
Ligand-Target Pair