BDBM23543 2-oxo-N-phenyl-2H-chromene-3-carboxamide::3-Carboxamide-coumarin deriv., 18::JMC521935 Compound 6

SMILES: O=C(Nc1ccccc1)c1cc2ccccc2oc1=O

InChI Key: InChIKey=IMFBGZCBLOPVCJ-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 23543   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Factor XIIa (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	4.20E+4	n/a	n/a	n/a	n/a	7.9	22
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration w...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair
Amine oxidase [flavin-containing] B (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	760	n/a	n/a	n/a	n/a	n/a	n/a
Universita degli Studi di Roma La Sapienza					Assay Description The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...				J Med Chem 52: 1935-42 (2009) Article DOI: 10.1021/jm801496u BindingDB Entry DOI: 10.7270/Q2SF2THN
					More data for this Ligand-Target Pair
Plasma kallikrein (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair
Amine oxidase (flavin-containing) A (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.31E+4	n/a	n/a	n/a	n/a	7.4	37
Universita degli Studi di Roma La Sapienza					Assay Description The effects of the test compounds on hMAO isoform enzymatic activity were evaluated by measuring their effects on the production of hydrogen peroxide...				J Med Chem 52: 1935-42 (2009) Article DOI: 10.1021/jm801496u BindingDB Entry DOI: 10.7270/Q2SF2THN
					More data for this Ligand-Target Pair
Coagulation factor VII (Homo sapiens (Human))	BDBM23543 (2-oxo-N-phenyl-2H-chromene-3-carboxamide | 3-Carbo...) Show SMILES O=C(Nc1ccccc1)c1cc2ccccc2oc1=O Show InChI InChI=1S/C16H11NO3/c18-15(17-12-7-2-1-3-8-12)13-10-11-6-4-5-9-14(11)20-16(13)19/h1-10H,(H,17,18)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Namur					Assay Description After substrate hydrolysis reaction, the absorbance at 405 nm was measured in a microplate reader. Percentages of inhibition at each concentration we...				J Med Chem 51: 3077-80 (2008) Article DOI: 10.1021/jm8002697 BindingDB Entry DOI: 10.7270/Q2610XNH
					More data for this Ligand-Target Pair