BDBM236566 US9365582, 7
SMILES: CCOc1cc(O[C@@H]2C[C@@H]3[C@@H](C2)C(=O)N(C)CCCC\C=C/[C@@H]2C[C@]2(NC3=O)C(=O)NS(=O)(=O)C2CC2)c2ccc(OC)c(Br)c2n1
InChI Key: InChIKey=SMGNMBKPAWFKGH-INOGULINSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NS3/4A protease (Hepatitis C virus genotype 1a (strain H77) (HCV)) | BDBM236566 (US9365582, 7) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | 7.5 | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description The inhibition of full-length hepatitis C NS3 protease enzyme was measured essentially as described in Poliakov, 2002 Prot Expression & Purification ... | US Patent US9365582 (2016) BindingDB Entry DOI: 10.7270/Q2VM4B5G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
NS3-NS5B (Hepatitis C virus genotype 1b (isolate Con1) (HCV)) | BDBM236566 (US9365582, 7) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 3.5 | n/a | n/a | n/a | n/a |
Janssen Sciences Ireland UC US Patent | Assay Description The assay utilized the stably transfected cell line Huh-7 luc/neo (hereafter referred to as Huh-Luc). This cell line harbors an RNA encoding a bicist... | US Patent US9365582 (2016) BindingDB Entry DOI: 10.7270/Q2VM4B5G | |||||||||||
More data for this Ligand-Target Pair |