BDBM238353 3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid (1a)

SMILES: CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1

InChI Key: InChIKey=LZPDVGLUWXGLPV-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 238353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Saccharomyces cerevisiae (Baker's yeast))	BDBM238353 (3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	7.5	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, prepared with Biomek NKMC and Biomek 3000 from Beckman Coulter and read on Wallac Victor fluorimeter from Per...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Protein farnesyltransferase alpha subunit/subunit beta (Trypanosoma brucei brucei)	BDBM238353 (3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.06E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for human FTase with the dansylated peptide Dansyl-GCAIM and the solution contains 15 μL of...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha (Homo sapiens (Human))	BDBM238353 (3-(4-Chlorophenyl)-4-cyano-5-(isopropylthio)thioph...) Show SMILES CC(C)Sc1sc(C(O)=O)c(c1C#N)-c1ccc(Cl)cc1 Show InChI InChI=1S/C15H12ClNO2S2/c1-8(2)20-15-11(7-17)12(13(21-15)14(18)19)9-3-5-10(16)6-4-9/h3-6,8H,1-2H3,(H,18,19)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+4	n/a	n/a	n/a	n/a	n/a	n/a
Centre de Recherche de Gif					Assay Description Assays were realized on 96-well plates, as described for yeast FTase but octyl-D-glucopyranoside (0.18%) was used instead of CHAPS and the solution c...				J Enzyme Inhib Med Chem 28: 163-71 (2013) Article DOI: 10.3109/14756366.2011.643302 BindingDB Entry DOI: 10.7270/Q2319TSJ
					More data for this Ligand-Target Pair