BDBM243350 4-{5-[3-(4-Methyl- pyrimidin-2-ylamino)-5- morpholin-4-ylmethyl- phenyl]-oxazol-2-yl}-4,7- diaza-spiro[2.5]octan-8- one::US10053455, 006

SMILES: Cc1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1

InChI Key: InChIKey=YHZYKKLEUYUFCJ-UHFFFAOYSA-N

Data: 1 IC50

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Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 243350   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM243350 (4-{5-[3-(4-Methyl- pyrimidin-2-ylamino)-5- morphol...) Show SMILES Cc1ccnc(Nc2cc(CN3CCOCC3)cc(c2)-c2cnc(o2)N2CCNC(=O)C22CC2)n1 Show InChI InChI=1S/C25H29N7O3/c1-17-2-5-27-23(29-17)30-20-13-18(16-31-8-10-34-11-9-31)12-19(14-20)21-15-28-24(35-21)32-7-6-26-22(33)25(32)3-4-25/h2,5,12-15H,3-4,6-11,16H2,1H3,(H,26,33)(H,27,29,30)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<500	n/a	n/a	n/a	n/a	7.8	25
AB SCIENCE US Patent					Assay Description SYK kinase was purified as a full length protein in a baculovirus system near homogeneity. All kinase assays were performed with the Kinase TK (tyros...				US Patent US10053455 (2018) BindingDB Entry DOI: 10.7270/Q27946PV
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