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SMILES: Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1

InChI Key: InChIKey=BYVUAJDYENVNAV-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 25195   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1 Show InChI InChI=1S/C21H17N3O/c1-14-4-6-17(25)12-21(14)24-20-8-10-23-19-7-5-15(11-18(19)20)16-3-2-9-22-13-16/h2-13,25H,1H3,(H,23,24)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	Article PubMed	n/a	n/a	80	n/a	n/a	n/a	n/a	7.4	22
GlaxoSmithKline					Assay Description The biochemical activity of compound was determined by incubation with Ret kinase and the substrate in the presence of ATP/ [gamma-33P] ATP. After in...				Bioorg Med Chem Lett 17: 5886-93 (2007) Article DOI: 10.1016/j.bmcl.2007.07.104 BindingDB Entry DOI: 10.7270/Q2H1309S
					More data for this Ligand-Target Pair
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human))	BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1 Show InChI InChI=1S/C21H17N3O/c1-14-4-6-17(25)12-21(14)24-20-8-10-23-19-7-5-15(11-18(19)20)16-3-2-9-22-13-16/h2-13,25H,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	PubMed	n/a	n/a	460	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of VEGFR2(unknown origin)				J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1 Show InChI InChI=1S/C21H17N3O/c1-14-4-6-17(25)12-21(14)24-20-8-10-23-19-7-5-15(11-18(19)20)16-3-2-9-22-13-16/h2-13,25H,1H3,(H,23,24)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	PubMed	n/a	n/a	3.74E+3	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Inhibition of p38alpha (unknown origin)				J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair
Receptor-interacting serine/threonine-protein kinase 2 (Homo sapiens (Human))	BDBM25195 (4-methyl-3-{[6-(pyridin-3-yl)quinolin-4-yl]amino}p...) Show SMILES Cc1ccc(O)cc1Nc1ccnc2ccc(cc12)-c1cccnc1 Show InChI InChI=1S/C21H17N3O/c1-14-4-6-17(25)12-21(14)24-20-8-10-23-19-7-5-15(11-18(19)20)16-3-2-9-22-13-16/h2-13,25H,1H3,(H,23,24)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents	PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
GlaxoSmithKline Curated by ChEMBL					Assay Description Competitive inhibition of full length FLAG-His-tagged RIP2K (unknown origin) expressed in baculovirus expression system preincubated for 10 mins foll...				J Med Chem 59: 4867-80 (2016) BindingDB Entry DOI: 10.7270/Q2G162SQ
					More data for this Ligand-Target Pair