BDBM25490 Dihydropyrimidine, 19::N-(1H-indazol-5-yl)-2-(4-methoxyphenyl)-6-methyl-4-(4-sulfamoylphenyl)-1,4-dihydropyrimidine-5-carboxamide

SMILES: COc1ccc(cc1)C1=NC(C)=C(C(N1)c1ccc(cc1)S(N)(=O)=O)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key: InChIKey=SXFFNERBTMUDJT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 25490   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Homo sapiens (Human))	BDBM25490 (Dihydropyrimidine, 19 | N-(1H-indazol-5-yl)-2-(4-m...) Show SMILES COc1ccc(cc1)C1=NC(C)=C(C(N1)c1ccc(cc1)S(N)(=O)=O)C(=O)Nc1ccc2[nH]ncc2c1 |c:12,t:9| Show InChI InChI=1S/C26H24N6O4S/c1-15-23(26(33)30-19-7-12-22-18(13-19)14-28-32-22)24(16-5-10-21(11-6-16)37(27,34)35)31-25(29-15)17-3-8-20(36-2)9-4-17/h3-14,24H,1-2H3,(H,28,32)(H,29,31)(H,30,33)(H2,27,34,35)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	68	n/a	n/a	n/a	n/a	7.4	22
GSK					Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP33, and the incorporation of P33 into the peptide was quantified by Sc...				J Med Chem 51: 6631-4 (2008) Article DOI: 10.1021/jm8005096 BindingDB Entry DOI: 10.7270/Q2F47MFZ
					More data for this Ligand-Target Pair