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SMILES: CCCc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12

InChI Key: InChIKey=UBFPILYJJMRTHR-UHFFFAOYSA-N

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 258394   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
cGMP-specific 3',5'-cyclic phosphodiesterase


(Homo sapiens (Human))
BDBM258394
PNG
(US9505786, 32)
Show SMILES CCCc1nc(nc2NC(=O)C(C)(C)c12)-c1nn(Cc2ccccc2F)c2ncccc12
Show InChI InChI=1S/C24H23FN6O/c1-4-8-17-18-20(29-23(32)24(18,2)3)28-21(27-17)19-15-10-7-12-26-22(15)31(30-19)13-14-9-5-6-11-16(14)25/h5-7,9-12H,4,8,13H2,1-3H3,(H,27,28,29,32)
PDB
MMDB

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PC cid
PC sid
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US Patent
n/an/a 110n/an/an/an/a7.525



BAYER PHARMA AKTIENGESELLSCHAFT; BAYER INTELLECTUAL PROPERTY GMBH

US Patent


Assay Description
To determine their in vitro action on human PDE 5, the test substances are dissolved in 100% DMSO and serially diluted. Typically, dilution series (1...


US Patent US9505786 (2016)


BindingDB Entry DOI: 10.7270/Q2WS8S6V
More data for this
Ligand-Target Pair