BDBM259847 US9505766, 51
SMILES: NC(=O)C(=C\c1cccc(c1)-n1cc(-c2ccc(Cl)cc2)c2c(N)ncnc12)\C#N
InChI Key: InChIKey=FNHJQTZZYISYDC-OVCLIPMQSA-N
Data: 5 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase BTK (Homo sapiens (Human)) | BDBM259847 (US9505766, 51) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | 25 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description Btk (human, full length) was purchased (Invitrogen, catalog number PV3363) and used as specified in the product literature. Btk (2 nM final concentra... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM259847 (US9505766, 51) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | ||||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene c-Src (S345C) (Homo sapiens (Human)) | BDBM259847 (US9505766, 51) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 520 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human)) | BDBM259847 (US9505766, 51) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 5.90E+3 | n/a | n/a | n/a | n/a | 7.4 | 25 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | Assay Description Wild-type and S345C mutant cSrc kinase domains were expressed and purified as described (Blair et al., Nat. Chem. Biol., 2007). The purified cSrc kin... | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
JAK3 (aa 781-1124) (Homo sapiens (Human)) | BDBM259847 (US9505766, 51) | PDB GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | 273 | n/a | n/a | n/a | n/a | n/a | n/a |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA US Patent | US Patent US9505766 (2016) BindingDB Entry DOI: 10.7270/Q2639NPR | ||||||||||||
More data for this Ligand-Target Pair |