BindingDB PrimarySearch

BDBM26121 SUCCINIC ACID::Substrate analogue, 11::Succinate::Succinic acid, 6::butanedioic acid::succinate, 9

SMILES: OC(=O)CCC(O)=O

InChI Key: InChIKey=KDYFGRWQOYBRFD-UHFFFAOYSA-N

Data: 2 KI 4 IC50 3 Kd 1 ITC

PDB links: 275 PDB IDs match this monomer. 777 PDB IDs contain this monomer as substructures. 777 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 26121
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycosylasparaginase (GA) (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	5.00E+6	-3.26	n/a	n/a	n/a	n/a	n/a	5.8	37
University of North Carolina					Assay Description Glycosylasparaginase activity was measured in citrate-phosphate buffer at pH 5.8 at 37 C. N-Acetyl-D-glucosamine released during the reaction was me...				J Enzym Inhib 16: 269-74 (2001) Article DOI: 10.1080/14756360109162375 BindingDB Entry DOI: 10.7270/Q2P55M2S
University of North Carolina					More data for this Ligand-Target Pair
Porphobilinogen synthase (Escherichia coli)	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.25E+7	-2.70	n/a	n/a	n/a	n/a	n/a	8.1	37
University of Neuchâtel					Assay Description The PBGS assay is a colorimetric assay based on the reaction between PBG and 4-dimethylaminobenzaldehyde (Ehrlich's reagent).				Chembiochem 2: 343-54 (2001) Article DOI: 10.1002/1439-7633(20010504)2 BindingDB Entry DOI: 10.7270/Q29Z93CN
University of Neuchâtel					More data for this Ligand-Target Pair
Prolyl 4-hydroxylase (Paramecium bursaria Chlorella virus 1)	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of N-terminal His6-tagged recombinant Paramecium bursaria chlorella virus 1 CPH expressed in Escherichia coli Rosetta 2 (DE3) cells pre-in...				Bioorg Med Chem 27: 2405-2412 (2019) Article DOI: 10.1016/j.bmc.2019.01.018
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Binding affinity to human PHD2-Mn(II) using 12.5% H2O/87.5% D2O MQC spectrometer operated at 500 MHz at 298K temperature				J Med Chem 53: 867-75 (2010) Article DOI: 10.1021/jm901537q BindingDB Entry DOI: 10.7270/Q2JD4WWN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Binding affinity to human PHD2 by nondenaturing ESI-MS				J Med Chem 53: 867-75 (2010) Article DOI: 10.1021/jm901537q BindingDB Entry DOI: 10.7270/Q2JD4WWN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+7	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of PHD2 (unknown origin)				J Med Chem 56: 547-55 (2013) Article DOI: 10.1021/jm301583m BindingDB Entry DOI: 10.7270/Q26Q1ZJV
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair
Methyl-accepting chemotaxis protein (McpS) (Pseudomonas putida (Arthrobacter siderocapsulatus))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	8.20E+4	n/a	n/a	n/a	n/a	20
CSIC					Assay Description Measurements were done on a VP-microcalorimeter (MicroCal, Amherst, MA).				J Biol Chem 285: 23126-36 (2010) Article DOI: 10.1074/jbc.M110.110403 BindingDB Entry DOI: 10.7270/Q2K64GNS
CSIC					More data for this Ligand-Target Pair
Histone Lysine Demethylase (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	7.10E+5	n/a	n/a	n/a	n/a	7.5	37
University of Oxford					Assay Description A coupled-assay for JMJD2E activity employing formaldehyde dehydrogenase (FDH) from Pseudomonas putida was developed. Formaldehyde release by demethy...				J Med Chem 51: 7053-6 (2008) Article DOI: 10.1021/jm800936s BindingDB Entry DOI: 10.7270/Q2959FV4
University of Oxford					More data for this Ligand-Target Pair
Egl nine homolog 1 (Homo sapiens (Human))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...) Show SMILES OC(=O)CCC(O)=O Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	8.53E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Oxford Curated by ChEMBL					Assay Description Inhibition of human PHD2 at 293K temperature by solvent relaxation technique				J Med Chem 53: 867-75 (2010) Article DOI: 10.1021/jm901537q BindingDB Entry DOI: 10.7270/Q2JD4WWN
University of Oxford Curated by ChEMBL					More data for this Ligand-Target Pair

Activity Spreadsheet -- ITC Data from BindingDB

Found 1 hit for monomerid = 26121
Cell (A)	Syringe (B)	Cell Links	Syringe Links	Cell + Syr Links	ΔG° kcal/mole	-TΔS° kcal/mole	ΔH° kcal/mole	log K	pH	Temp °C
Methyl-accepting chemotaxis protein (McpS) (Pseudomonas putida (Arthrobacter siderocapsulatus))	BDBM26121 (SUCCINIC ACID \| Substrate analogue, 11 \| Succinate...)	GoogleScholar	CHEBI MMDB PC cid PC sid PDB		-5.48	4.90	-10.2	4.09	n/a	20
CSIC		GoogleScholar	CHEBI MMDB PC cid PC sid PDB		J Biol Chem 285: 23126-36 (2010)