null

SMILES: Cc1n[nH]c2nc(nc(OC3CCC(O)CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1

InChI Key: InChIKey=FJHKQZFRXVLCAZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 268810   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268810 (US9718825, Example 215) Show SMILES Cc1n[nH]c2nc(nc(OC3CCC(O)CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |(8.24,.5,;7.09,-.53,;7.25,-2.06,;5.85,-2.68,;4.82,-1.54,;3.28,-1.54,;2.51,-.21,;3.28,1.13,;4.82,1.13,;5.59,2.46,;4.82,3.79,;5.59,5.13,;4.82,6.46,;3.28,6.46,;2.51,7.8,;2.51,5.13,;3.28,3.79,;5.59,-.21,;.97,-.21,;.2,-1.54,;-1.34,-1.54,;-2.11,-.21,;-3.65,-.21,;-4.42,-1.54,;-5.19,-2.87,;-3.09,-2.31,;-5.76,-.77,;-5.76,.77,;-7.09,1.54,;-7.09,3.08,;-8.43,.77,;-8.43,-.77,;-7.09,-1.54,;-7.09,-3.08,;-1.34,1.13,;.2,1.13,)| Show InChI InChI=1S/C24H23ClFN5O4S/c1-13-21-23(30-29-13)27-22(28-24(21)35-18-9-7-17(32)8-10-18)14-2-5-16(6-3-14)31-36(33,34)20-12-15(25)4-11-19(20)26/h2-6,11-12,17-18,31-32H,7-10H2,1H3,(H,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<1.5	n/a	n/a	n/a	n/a	7.4	n/a
SANOFI US Patent					Assay Description The compounds were tested for serum and glucocorticoid-regulated kinase 1 (SGK-1) inhibitory activity in a substrate phosphorylation assay designed t...				US Patent US9718825 (2017) BindingDB Entry DOI: 10.7270/Q2VM4F82
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268810 (US9718825, Example 215) Show SMILES Cc1n[nH]c2nc(nc(OC3CCC(O)CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |(8.24,.5,;7.09,-.53,;7.25,-2.06,;5.85,-2.68,;4.82,-1.54,;3.28,-1.54,;2.51,-.21,;3.28,1.13,;4.82,1.13,;5.59,2.46,;4.82,3.79,;5.59,5.13,;4.82,6.46,;3.28,6.46,;2.51,7.8,;2.51,5.13,;3.28,3.79,;5.59,-.21,;.97,-.21,;.2,-1.54,;-1.34,-1.54,;-2.11,-.21,;-3.65,-.21,;-4.42,-1.54,;-5.19,-2.87,;-3.09,-2.31,;-5.76,-.77,;-5.76,.77,;-7.09,1.54,;-7.09,3.08,;-8.43,.77,;-8.43,-.77,;-7.09,-1.54,;-7.09,-3.08,;-1.34,1.13,;.2,1.13,)| Show InChI InChI=1S/C24H23ClFN5O4S/c1-13-21-23(30-29-13)27-22(28-24(21)35-18-9-7-17(32)8-10-18)14-2-5-16(6-3-14)31-36(33,34)20-12-15(25)4-11-19(20)26/h2-6,11-12,17-18,31-32H,7-10H2,1H3,(H,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01601 BindingDB Entry DOI: 10.7270/Q2P55SCW
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase Sgk1 (Homo sapiens (Human))	BDBM268810 (US9718825, Example 215) Show SMILES Cc1n[nH]c2nc(nc(OC3CCC(O)CC3)c12)-c1ccc(NS(=O)(=O)c2cc(Cl)ccc2F)cc1 |(8.24,.5,;7.09,-.53,;7.25,-2.06,;5.85,-2.68,;4.82,-1.54,;3.28,-1.54,;2.51,-.21,;3.28,1.13,;4.82,1.13,;5.59,2.46,;4.82,3.79,;5.59,5.13,;4.82,6.46,;3.28,6.46,;2.51,7.8,;2.51,5.13,;3.28,3.79,;5.59,-.21,;.97,-.21,;.2,-1.54,;-1.34,-1.54,;-2.11,-.21,;-3.65,-.21,;-4.42,-1.54,;-5.19,-2.87,;-3.09,-2.31,;-5.76,-.77,;-5.76,.77,;-7.09,1.54,;-7.09,3.08,;-8.43,.77,;-8.43,-.77,;-7.09,-1.54,;-7.09,-3.08,;-1.34,1.13,;.2,1.13,)| Show InChI InChI=1S/C24H23ClFN5O4S/c1-13-21-23(30-29-13)27-22(28-24(21)35-18-9-7-17(32)8-10-18)14-2-5-16(6-3-14)31-36(33,34)20-12-15(25)4-11-19(20)26/h2-6,11-12,17-18,31-32H,7-10H2,1H3,(H,27,28,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	<2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SGK1 expressed in baculovirus expression system using 5-carboxyfluorescein -RPRAATF-NH2 as substrate preincubated for...				Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01601 BindingDB Entry DOI: 10.7270/Q2P55SCW
					More data for this Ligand-Target Pair